Regression of canine oral papillomas is associated with infiltration of CDA+ and CD8+ lymphocytes

Philip K. Nicholls, Peter F Moore, Davina M. Anderson, Richard A. Moore, Nigel R. Parry, Gerald W. Gough, Margaret A. Stanley

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRcαβ-, TCR-γδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. The lymphocyte infiltrate in the dog resembled that in human papillomavirus lesions, indicating that COPV is an appropriate model for human papillomavirus immunity.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
Issue number1
StatePublished - Apr 25 2001


  • Animal models
  • COPV
  • HPV
  • Immunity
  • Immunohistochemistry

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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