Registration-based morphometry for shape analysis of the bones of the human wrist

Anand A. Joshi, Richard M. Leahy, Ramsey D Badawi, Abhijit Chaudhari

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We present a method that quantifies point-wise changes in surface morphology of the bones of the human wrist. The proposed method, referred to as Registration-based Bone Morphometry (RBM), consists of two steps: an atlas selection step and an atlas warping step. The atlas for individual wrist bones was selected based on the shortest l2 distance to the ensemble of wrist bones from a database of a healthy population of subjects. The selected atlas was then warped to the corresponding bones of individuals in the population using a non-linear registration method based on regularized l2 distance minimization. The displacement field thus calculated showed local differences in bone shape that then were used for the analysis of group differences. Our results indicate that RBM has potential to provide a standardized approach to shape analysis of bones of the human wrist. We demonstrate the performance of RBM for examining group differences in wrist bone shapes based on sex and between those of the right and left wrists in healthy individuals. We also present data to show the application of RBM for tracking bone erosion status in rheumatoid arthritis.

Original languageEnglish (US)
Article number2476817
Pages (from-to)416-426
Number of pages11
JournalIEEE Transactions on Medical Imaging
Issue number2
StatePublished - Feb 1 2016


  • Arthritis
  • Carpal bones
  • Image registration
  • Sex differences
  • Shape analysis
  • Wrist

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Radiological and Ultrasound Technology
  • Software


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