Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes

Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen, Fengshan Wang, Hongzhi Cao

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic α2-6-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.

Original languageEnglish (US)
Pages (from-to)5205-5208
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number14
DOIs
StatePublished - Apr 9 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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