Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis

Laurent Younes, J. Tilak Ratnanather, Timothy Brown, Elizabeth Aylward, Peg Nopoulos, Hans Johnson, Vincent A. Magnotta, Jane S. Paulsen, Russell L. Margolis, Roger L. Albin, Michael I. Miller, Christopher A. Ross, Thomas Wassink, Stephen Cross, Mycah Kimble, Patricia Ryan, Eric A. Epping, Edmond Chiu, Olga Yastrubetskaya, Joy PrestonAnita Goh, D. Psych, Stephanie Antonopoulos, Samantha Loi, Phyllis Chua, Angela Komiti, Lynn Raymond, Joji Decolongon, Mark Varvaris, William M. Mallonee, Greg Suter, Ali Samii, Alma Macaraeg, Randi Jones, Cathy Wood-Siverio, Stewart A. Factor, Claudia Testa, Roger A. Barker, Sarah Mason, Elizabeth McCusker, Jane Griffith, Clement Loy, David Gunn, Michael Orth, Sigurd Sübmuth, Katrin Barth, Sonja Trautmann, Kimberly Quaid, Melissa Wesson, Joanne Wojcieszek, Mark Guttman, Alanna Sheinberg, Irita Karmalkar, Susan Perlman, Brian Clemente, Michael D. Geschwind, Gail Kang, Gabriela Satris, Tom Warner, Maggie Burrows, Anne Rosser, Kathy Price, Sarah Hunt, Frederick Marshall, Amy Chesire, Mary Wodarski, Charlyne Hickey, Peter Panegyres, Joseph Lee, Steve Andrew, Joel Perlmutter, Stacey Barton, Amy Schmidt, Zosia Miedzybrodzka, Daniela Rae, Mariella D'Alessandro, David Craufurd, Judith Bek, Elizabeth Howard, Pietro Mazzoni, Karen Marder, Paula Wasserman, Rajeev Kumar, Diane Erickson, Vicki L Wheelock, Terry Tempkin, Lisa Kjer, Wayne Martin, Pamela King, Marguerite Wieler, Satwinder Sran, Oksana Suchowersky, Anwar Ahmed, Stephen Rao, Christine Reece, Alex Bura, Lyla Mourany, Juliet Schulz, Jeffrey D. Long, Kelsey Montross, Jeremy Bockholt, Steve Blanchard, Ken Evans, Wayne Matson, Asa Peterson, James A. Mills, Jean Paul Vonsattel, Carol Moskowitz, Stacie Vik, Deborah Harrington, Gabriel Castillo, Jessica Morison, Jason Reed, Michael Diaz, Ian Dobbins, Tamara Hershey, Erin Foster, Deborah Moore, Holly Westervelt, Jennifer Davis, Geoff Tremont, J. David, Carissa Gehl, Kirsty Matheson, Karen Siedlecki, Marleen Van Walsem, Greg Elias, Mary Gover, Rachel Bernier, Noelle Carlozzi, Kevin Duff, Georgiou-Karistianis Nellie Georgiou-Karistianis, Kate Papp, Janet Willia, Lee Anna Clark, Nancy Downing, Michelle Harreld, Rebecca Ready, Anthony Vaccarino, Sarah E Tomaszewski Farias, Marcy MacDonald, Jim Gusella, Rick Myers, Tom Wassink, Christopher Ross, Kathy Jones, Jacquie Marietta, Greg Harris, Eun Young Kim, Greg Ennis, John Ashburner, Steve Potkin, Arthur Toga, Eric Axelson, Michael Miller, Sarah Reading, Mirza Faisal Beg, Karl Helmer, Kelvin Lim, Mark Lowe, Sasumu Mori, Allen Song, Jessica Turner, Erik Beall, Katherine Koenig, Michael Phillips, Jan Zimbelman, Jess Fiedorowicz, Robert Robinson, Megan Smith, Leigh Beglinger, Janet Williams, Dawei Liu, David Moser, Kelly Rowe, Karen Anderson, Mark Groves, Hugh Rickards, Eric Van Duijn, Ji In Kim, Ying Zhang, Wenjing Lu, Craig Stout, Spencer Lourens, Martha Nance, Sean Thompson, Cheryl Erwin, Lisa Hughes, Jim Smith, Roland Zschiegner, Ryan Wyse, Owen Wade, Derek Weston, Chris Werling-Witkoske, Karla Anderson, Brittany Lichty, Leann Davis, Phil Danzer

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.

Original languageEnglish (US)
Pages (from-to)792-809
Number of pages18
JournalHuman Brain Mapping
Volume35
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Diffeomorphic mapping
  • Pallidus atrophy
  • Striatal atrophy
  • Surface registration
  • Surface-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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