Regional ventilation and distribution of emphysema - A quantitative comparison

Åke Johansson, Jenny Vikgren, Michaela Moonen, Ulf Tylen, Björn Bake

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The distribution of ventilation and emphysema throughout the lung was compared in 20 emphysematous patients who were candidates for lung volume reduction surgery. Ventilation distribution among 1.6-cm-high stripe regions was obtained in supine position by planar gamma camera scintigraphy after inhalation of technegas®. Results from nine healthy subjects provided normal stripe count rates. Patient count rates were expressed as the difference from predicted normal stripe count rate (ΔSVI). Thus, ΔSVI is a relative index of abnormal ventilation. Emphysema was assessed quantitatively by a density mask method on corresponding slices of high resolution computed tomography (HRCT). The results show that in the majority of patients, there is a highly significant relationship between the degree of stripe hypoventilation and the amount of distribution of emphysema, but in some patients no such relationship is found. We speculate that the distribution of airway obstruction not necessarily follows the distribution of emphysema, which could explain the lack of concordance between ventilation and emphysema distribution in some patients. We conclude that ventilation scintigraphy contains complementary information to lung HRCT.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalClinical Physiology and Functional Imaging
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Chest X-ray
  • Comparison
  • COPD
  • Function
  • Healthy volunteers
  • Lung
  • Pulmonary function
  • Quantification
  • Radioisotope
  • Regions of interest (ROI)
  • Technegas

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'Regional ventilation and distribution of emphysema - A quantitative comparison'. Together they form a unique fingerprint.

Cite this