Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging

John G. Sled, I. Levesque, A. C. Santos, S. J. Francis, S. Narayanan, S. D. Brass, D. L. Arnold, G. B. Pike

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

A quantitative magnetization transfer imaging (qMTI) study, based on a two-pool model of magnetization transfer, was performed on seven normal subjects to determine, on a regional basis, normal values for the pool sizes, exchange, and relaxation parameters that characterize the MT phenomenon. Regions were identified on high-resolution anatomical scans using a combination of manual and automatic methods. Only voxels identified as pure tissue at the resolution of the quantitative scans were considered for analysis. While no left/right differences were observed, significant differences were found among white-matter regions and gray-matter regions. These regional differences were compared with existing cytoarchitectural data. In addition, the pattern and magnitude of the regional differences observed in white matter was found to be different from that reported previously for an alternative putative MRI measure of myelination, the 10-50-ms T2 component described as myelin water.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalMagnetic Resonance in Medicine
Volume51
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Fingerprint

Brain
Myelin Sheath
Reference Values
Water
White Matter
Gray Matter

Keywords

  • Magnetization transfer
  • Myelin
  • Quantitative imaging
  • T relaxation
  • White matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sled, J. G., Levesque, I., Santos, A. C., Francis, S. J., Narayanan, S., Brass, S. D., ... Pike, G. B. (2004). Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging. Magnetic Resonance in Medicine, 51(2), 299-303. https://doi.org/10.1002/mrm.10701

Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging. / Sled, John G.; Levesque, I.; Santos, A. C.; Francis, S. J.; Narayanan, S.; Brass, S. D.; Arnold, D. L.; Pike, G. B.

In: Magnetic Resonance in Medicine, Vol. 51, No. 2, 02.2004, p. 299-303.

Research output: Contribution to journalArticle

Sled, JG, Levesque, I, Santos, AC, Francis, SJ, Narayanan, S, Brass, SD, Arnold, DL & Pike, GB 2004, 'Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging', Magnetic Resonance in Medicine, vol. 51, no. 2, pp. 299-303. https://doi.org/10.1002/mrm.10701
Sled JG, Levesque I, Santos AC, Francis SJ, Narayanan S, Brass SD et al. Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging. Magnetic Resonance in Medicine. 2004 Feb;51(2):299-303. https://doi.org/10.1002/mrm.10701
Sled, John G. ; Levesque, I. ; Santos, A. C. ; Francis, S. J. ; Narayanan, S. ; Brass, S. D. ; Arnold, D. L. ; Pike, G. B. / Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging. In: Magnetic Resonance in Medicine. 2004 ; Vol. 51, No. 2. pp. 299-303.
@article{a4f0f4a420ea4c97ace2fe33e9ec0736,
title = "Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging",
abstract = "A quantitative magnetization transfer imaging (qMTI) study, based on a two-pool model of magnetization transfer, was performed on seven normal subjects to determine, on a regional basis, normal values for the pool sizes, exchange, and relaxation parameters that characterize the MT phenomenon. Regions were identified on high-resolution anatomical scans using a combination of manual and automatic methods. Only voxels identified as pure tissue at the resolution of the quantitative scans were considered for analysis. While no left/right differences were observed, significant differences were found among white-matter regions and gray-matter regions. These regional differences were compared with existing cytoarchitectural data. In addition, the pattern and magnitude of the regional differences observed in white matter was found to be different from that reported previously for an alternative putative MRI measure of myelination, the 10-50-ms T2 component described as myelin water.",
keywords = "Magnetization transfer, Myelin, Quantitative imaging, T relaxation, White matter",
author = "Sled, {John G.} and I. Levesque and Santos, {A. C.} and Francis, {S. J.} and S. Narayanan and Brass, {S. D.} and Arnold, {D. L.} and Pike, {G. B.}",
year = "2004",
month = "2",
doi = "10.1002/mrm.10701",
language = "English (US)",
volume = "51",
pages = "299--303",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Regional Variations in Normal Brain Shown by Quantitative Magnetization Transfer Imaging

AU - Sled, John G.

AU - Levesque, I.

AU - Santos, A. C.

AU - Francis, S. J.

AU - Narayanan, S.

AU - Brass, S. D.

AU - Arnold, D. L.

AU - Pike, G. B.

PY - 2004/2

Y1 - 2004/2

N2 - A quantitative magnetization transfer imaging (qMTI) study, based on a two-pool model of magnetization transfer, was performed on seven normal subjects to determine, on a regional basis, normal values for the pool sizes, exchange, and relaxation parameters that characterize the MT phenomenon. Regions were identified on high-resolution anatomical scans using a combination of manual and automatic methods. Only voxels identified as pure tissue at the resolution of the quantitative scans were considered for analysis. While no left/right differences were observed, significant differences were found among white-matter regions and gray-matter regions. These regional differences were compared with existing cytoarchitectural data. In addition, the pattern and magnitude of the regional differences observed in white matter was found to be different from that reported previously for an alternative putative MRI measure of myelination, the 10-50-ms T2 component described as myelin water.

AB - A quantitative magnetization transfer imaging (qMTI) study, based on a two-pool model of magnetization transfer, was performed on seven normal subjects to determine, on a regional basis, normal values for the pool sizes, exchange, and relaxation parameters that characterize the MT phenomenon. Regions were identified on high-resolution anatomical scans using a combination of manual and automatic methods. Only voxels identified as pure tissue at the resolution of the quantitative scans were considered for analysis. While no left/right differences were observed, significant differences were found among white-matter regions and gray-matter regions. These regional differences were compared with existing cytoarchitectural data. In addition, the pattern and magnitude of the regional differences observed in white matter was found to be different from that reported previously for an alternative putative MRI measure of myelination, the 10-50-ms T2 component described as myelin water.

KW - Magnetization transfer

KW - Myelin

KW - Quantitative imaging

KW - T relaxation

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=0842264087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842264087&partnerID=8YFLogxK

U2 - 10.1002/mrm.10701

DO - 10.1002/mrm.10701

M3 - Article

C2 - 14755655

AN - SCOPUS:0842264087

VL - 51

SP - 299

EP - 303

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -