Regional (14C) 2-deoxyglucose uptake during vibrissae movements evoked by rat motor cortex stimulation

Frank R Sharp, K. Evans

Research output: Contribution to journalArticle

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Abstract

Repetitive left mystacial vibrissae movements were produced by electrical stimulation of right motor cortex (MI) with a bipolar electrode in the alert, unanesthetized rat. Regional increases of (14C) 2-deoxyglucose (2DG) uptake were mapped autoradiographically during these left vibrissae movements. Uptake of 2DG increased in a 2-4 mm-diameter area about the stimulating electrode in right MI and in a smaller region in left MI cortex. Columnar increases of 2DG uptake occurred bilaterally in somatosensory cortex in the face region of somatosensory cortex (SI). Bilateral increases of 2DG uptake occurred subcortically in dorsolateral caudate-putamen (CP) and subthalamic nucleus. Primarily right-sided increases of 2DG uptake occurred in other basal ganglia structures including dorsal globus pallidus (GP), posterior entopeducur nucleus (EPN), ventrolateral substantia nigra pars reticulata (SN[r]), and anterolateral substantia nigra pars compacta (SN[c]). Uptake of 2DG increased on the right side of the following thalamic regions: much of the ventrolateral (VL) nucleus, particularly dorsally; the anterodorsal reticular nucleus; dorsolateral posteromedial (PO[m]) nucleus; the ventromedial nucleus; and dorsolateral parafascicular nucleus. The anterior and ventral posterior portions of VL were not activated. Caudal to thalamus right-sided 2DG uptake increased in the medial, ventral, and lateral pontine nuclei, deep layers of superior colliculus, lateral deep mesencephalic nucleus (DMN), and nucleus cuneiformis (NCU). Uptake of 2DG increases in right rostral parvocellular red nucleus in a few animals. Discrete portions of the right internal capsule and right medial pyramidal tract increased 2DG uptake during MI stimulation. Uptake of 2DG increased on the left side of the brain during right MI stimulation in the left lateral nucleus (NL) of cerebellum and in several discrete regions of left cerebellar hemisphere granule cells including anterior paravermis, lobulus simplex, crus II, and the paramedian lobule. Uptake of 2DG increased in left nucleus of the spinal tract of the trigeminal nerve (ntV) ventrally in subnuclei interpolaris and oralis. Left lateral portions of the facial nucleus are known to project to vibrissae musculature. All of the above structures may be involved in the motor-sensory processing responsible for vibrissae movements. Regions not previously suggested to play a major role in the vibrillsae movements include DMN and NCU. Though NCU has been called the 'locomotor center' it may play a role in facial movements as well. Polysynaptic activation of GP, EPN, NL, and cerebellar hemisphere occurred since no connections between MI and these regions exist. A pathway from ntV to POm to MI and SI is suggested to provide proprioceptive input to motor-sensory cortex from the moving vibrissae since neither the principal trigeminal sensory nucleus nor the ventrobasal nucleus of thalamus increased 2DG uptake during MI stimulation.

Original languageEnglish (US)
Pages (from-to)255-287
Number of pages33
JournalJournal of Comparative Neurology
Volume208
Issue number3
StatePublished - 1982

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Vibrissae
Deoxyglucose
Motor Cortex
Globus Pallidus
Somatosensory Cortex
Thalamus
Electrodes
Anterior Thalamic Nuclei
Intralaminar Thalamic Nuclei
Trigeminal Nuclei
Red Nucleus
Ventral Thalamic Nuclei
Internal Capsule
Cerebellar Nuclei
Subthalamic Nucleus
Pyramidal Tracts
Trigeminal Nerve
Superior Colliculi
Caudate Nucleus
Putamen

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Regional (14C) 2-deoxyglucose uptake during vibrissae movements evoked by rat motor cortex stimulation. / Sharp, Frank R; Evans, K.

In: Journal of Comparative Neurology, Vol. 208, No. 3, 1982, p. 255-287.

Research output: Contribution to journalArticle

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