Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia

Marc L. Schröder, Jan Paul Muizelaar, Panos P. Fatouros, A. John Kuta, Sung C. Choi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.

Original languageEnglish (US)
Pages (from-to)1276-1281
Number of pages6
JournalNeurosurgery
Volume42
Issue number6
DOIs
StatePublished - Jun 1998

Fingerprint

Cerebrovascular Circulation
Brain Ischemia
Craniocerebral Trauma
Ischemia
Tomography
Xenon
Microvessels
Cerebral Blood Volume
Reference Values

Keywords

  • Cerebral blood flow
  • Cerebral blood volume
  • Head injury
  • Ischemia
  • Microvasculature
  • Vasospasm

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia. / Schröder, Marc L.; Muizelaar, Jan Paul; Fatouros, Panos P.; Kuta, A. John; Choi, Sung C.

In: Neurosurgery, Vol. 42, No. 6, 06.1998, p. 1276-1281.

Research output: Contribution to journalArticle

Schröder, Marc L. ; Muizelaar, Jan Paul ; Fatouros, Panos P. ; Kuta, A. John ; Choi, Sung C. / Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia. In: Neurosurgery. 1998 ; Vol. 42, No. 6. pp. 1276-1281.
@article{5dc97b8d23574803867ce87571728c64,
title = "Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia",
abstract = "OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.",
keywords = "Cerebral blood flow, Cerebral blood volume, Head injury, Ischemia, Microvasculature, Vasospasm",
author = "Schr{\"o}der, {Marc L.} and Muizelaar, {Jan Paul} and Fatouros, {Panos P.} and Kuta, {A. John} and Choi, {Sung C.}",
year = "1998",
month = "6",
doi = "10.1097/00006123-199806000-00042",
language = "English (US)",
volume = "42",
pages = "1276--1281",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia

AU - Schröder, Marc L.

AU - Muizelaar, Jan Paul

AU - Fatouros, Panos P.

AU - Kuta, A. John

AU - Choi, Sung C.

PY - 1998/6

Y1 - 1998/6

N2 - OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.

AB - OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.

KW - Cerebral blood flow

KW - Cerebral blood volume

KW - Head injury

KW - Ischemia

KW - Microvasculature

KW - Vasospasm

UR - http://www.scopus.com/inward/record.url?scp=0345367905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345367905&partnerID=8YFLogxK

U2 - 10.1097/00006123-199806000-00042

DO - 10.1097/00006123-199806000-00042

M3 - Article

C2 - 9632185

AN - SCOPUS:0345367905

VL - 42

SP - 1276

EP - 1281

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 6

ER -