Abstract
OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1276-1281 |
| Number of pages | 6 |
| Journal | Neurosurgery |
| Volume | 42 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1998 |
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Keywords
- Cerebral blood flow
- Cerebral blood volume
- Head injury
- Ischemia
- Microvasculature
- Vasospasm
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia. / Schröder, Marc L.; Muizelaar, Jan Paul; Fatouros, Panos P.; Kuta, A. John; Choi, Sung C.
In: Neurosurgery, Vol. 42, No. 6, 06.1998, p. 1276-1281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia
AU - Schröder, Marc L.
AU - Muizelaar, Jan Paul
AU - Fatouros, Panos P.
AU - Kuta, A. John
AU - Choi, Sung C.
PY - 1998/6
Y1 - 1998/6
N2 - OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.
AB - OBJECTIVE: Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality. METHODS: For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas. RESULTS: Both CBF (15 ± 4.3 versus 34 ± 11 g/min, P < 0.002) and CBV (2.5 ± 1.0 versus 4.9 ± 1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means ± standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range. CONCLUSION: These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.
KW - Cerebral blood flow
KW - Cerebral blood volume
KW - Head injury
KW - Ischemia
KW - Microvasculature
KW - Vasospasm
UR - http://www.scopus.com/inward/record.url?scp=0345367905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345367905&partnerID=8YFLogxK
U2 - 10.1097/00006123-199806000-00042
DO - 10.1097/00006123-199806000-00042
M3 - Article
C2 - 9632185
AN - SCOPUS:0345367905
VL - 42
SP - 1276
EP - 1281
JO - Neurosurgery
JF - Neurosurgery
SN - 0148-396X
IS - 6
ER -