Abstract
Children with 22q11.2 microdeletions (Velocardiofacial Syndrome; VCFS) have previously been shown to exhibit learning deficits and elevated rates of psychopathology. The aim of this study was to assess regional brain abnormalities in children with 22q11DS, and to determine the relationship of these measures to neurocognitive and behavioral function. Thirteen children with confirmed deletions and 9 demographically matched comparison subjects were assessed with a neurocognitive battery, behavioral measures, and high-resolution MRI. Twenty-two q11DS children showed a nonsignificant 4.3% global decrease in total brain volume as compared to healthy controls, with differential reduction in white matter, and significantly increased sulcal cerebrospinal fluid (CSF) in temporal and posterior brain regions. In 22q11DS subjects, but not controls, bilateral temporal gray and white matter volumes were significant predictors of overall cognitive performance. Further, reduced temporal gray matter was associated with elevated Thought Problems score on the CBCL. Results indicate that global alterations in brain volume are common in children with 22q deletions, particularly those with low IQ and/or behavioral disturbance. Although preliminary, these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome, and provide insight into complex gene-brain-behavior relationships.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 198-206 |
| Number of pages | 9 |
| Journal | Neurocase |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Psychiatry and Mental health
- Psychology(all)
Cite this
Regional brain abnormalities in 22q11.2 deletion syndrome : Association with cognitive abilities and behavioral symptoms. / Bearden, Carrie E.; van Erp, Theo G M; Monterosso, John R.; Simon, Tony J; Glahn, David C.; Saleh, Peter A.; Hill, Nicole M.; McDonald-McGinn, Donna M.; Zackai, Elaine; Emanuel, Beverly S.; Cannon, Tyrone D.
In: Neurocase, Vol. 10, No. 3, 06.2004, p. 198-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional brain abnormalities in 22q11.2 deletion syndrome
T2 - Association with cognitive abilities and behavioral symptoms
AU - Bearden, Carrie E.
AU - van Erp, Theo G M
AU - Monterosso, John R.
AU - Simon, Tony J
AU - Glahn, David C.
AU - Saleh, Peter A.
AU - Hill, Nicole M.
AU - McDonald-McGinn, Donna M.
AU - Zackai, Elaine
AU - Emanuel, Beverly S.
AU - Cannon, Tyrone D.
PY - 2004/6
Y1 - 2004/6
N2 - Children with 22q11.2 microdeletions (Velocardiofacial Syndrome; VCFS) have previously been shown to exhibit learning deficits and elevated rates of psychopathology. The aim of this study was to assess regional brain abnormalities in children with 22q11DS, and to determine the relationship of these measures to neurocognitive and behavioral function. Thirteen children with confirmed deletions and 9 demographically matched comparison subjects were assessed with a neurocognitive battery, behavioral measures, and high-resolution MRI. Twenty-two q11DS children showed a nonsignificant 4.3% global decrease in total brain volume as compared to healthy controls, with differential reduction in white matter, and significantly increased sulcal cerebrospinal fluid (CSF) in temporal and posterior brain regions. In 22q11DS subjects, but not controls, bilateral temporal gray and white matter volumes were significant predictors of overall cognitive performance. Further, reduced temporal gray matter was associated with elevated Thought Problems score on the CBCL. Results indicate that global alterations in brain volume are common in children with 22q deletions, particularly those with low IQ and/or behavioral disturbance. Although preliminary, these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome, and provide insight into complex gene-brain-behavior relationships.
AB - Children with 22q11.2 microdeletions (Velocardiofacial Syndrome; VCFS) have previously been shown to exhibit learning deficits and elevated rates of psychopathology. The aim of this study was to assess regional brain abnormalities in children with 22q11DS, and to determine the relationship of these measures to neurocognitive and behavioral function. Thirteen children with confirmed deletions and 9 demographically matched comparison subjects were assessed with a neurocognitive battery, behavioral measures, and high-resolution MRI. Twenty-two q11DS children showed a nonsignificant 4.3% global decrease in total brain volume as compared to healthy controls, with differential reduction in white matter, and significantly increased sulcal cerebrospinal fluid (CSF) in temporal and posterior brain regions. In 22q11DS subjects, but not controls, bilateral temporal gray and white matter volumes were significant predictors of overall cognitive performance. Further, reduced temporal gray matter was associated with elevated Thought Problems score on the CBCL. Results indicate that global alterations in brain volume are common in children with 22q deletions, particularly those with low IQ and/or behavioral disturbance. Although preliminary, these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome, and provide insight into complex gene-brain-behavior relationships.
UR - http://www.scopus.com/inward/record.url?scp=7244229690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7244229690&partnerID=8YFLogxK
U2 - 10.1080/13554790490495519
DO - 10.1080/13554790490495519
M3 - Article
C2 - 15788257
AN - SCOPUS:7244229690
VL - 10
SP - 198
EP - 206
JO - Neurocase
JF - Neurocase
SN - 1355-4794
IS - 3
ER -