Regenerative sodium and calcium currents in goldfish retinal ganglion cell somata

Andrew Ishida

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Whole-cell patch-clamp recordings were made from isolated goldfish retinal ganglion cell somata. Sodium- and calcium-dependent action potentials-blocked with tetrodotoxin (TTX) and Co+ ions, respectively-were evoked under current-clamp. Depolarization of these somata under voltage clamp activated distinguishable Na+ and Ca2+ conductances: the former was permeable to Na+, blocked by TTX, impermeable to N-methyl-d-glucamine and tris(hydroxymethyl)aminomethane, and began to activate around -45 mV; the latter were permeable to Ca2+, but not Co2+, and began to activate around -55 mV. These results are consistent with recordings from carp, frog, salamander and rat retinal ganglion cells.

Original languageEnglish (US)
Pages (from-to)477-485
Number of pages9
JournalVision Research
Volume31
Issue number3
DOIs
StatePublished - 1991

Keywords

  • Action potentials
  • Calcium currents
  • Retinal ganglion cells
  • Sodium currents
  • Whole-cell patch clamp

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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