Regenerative Medicine of the Respiratory Tract

Martin A. Birchall, Sam Janes, Paolo Macchiarini

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter presents an overview of regenerative medicine of the respiratory tract. Olfactory ensheathing cells are a class of glial cells, which support regeneration of olfactory receptor neurons in the olfactory epithelium. When transplanted to other regions of the brain they may support regeneration of other classes of neurons. They also support axon regeneration and are successfully employed in rat models of spinal cord regeneration. Human nasal septum is a good source of chondrogenic cells with the potential to be used to engineer transplants for restorative surgery in otolaryngology. Partial laryngeal reconstruction is required for stenosis in children and adults and after resection of carcinomas in adults. Conventional means of restoring subglottic lumen include endoscopic techniques, which need repeating, large segmental resections, or the insertion of rib cartilage grafts. The synthetic or biological scaffolds may form the basis for myoblast progenitor cell proliferation and differentiation. The use of dynamic bioreactor "preconditioning" causes fiber-type differentiation into the appropriate MyHC subtypes (slow versus various forms of fast fibers) and, crucially, orientation of myotubes. The only curative treatment of any tracheal lesions involving less than 50% of the total length of the trachea is achieved by segmental resection followed by tracheal mobilization and primary end-to-end anastomosis in adults and/or slide tracheoplasty in children with long-segment tracheal stenosis.

Original languageEnglish (US)
Title of host publicationPrinciples of Regenerative Medicine
PublisherElsevier Inc.
Pages1079-1090
Number of pages12
ISBN (Print)9780123814227
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Regenerative Medicine
Respiratory System
Neurons
Regeneration
Odorant Receptors
Transplants
Forms (concrete)
Fibers
Cell proliferation
Cartilage
Scaffolds (biology)
Bioreactors
Spinal Cord Regeneration
Grafts
Olfactory Receptor Neurons
Surgery
Tracheal Stenosis
Nasal Septum
Rats
Olfactory Mucosa

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Birchall, M. A., Janes, S., & Macchiarini, P. (2011). Regenerative Medicine of the Respiratory Tract. In Principles of Regenerative Medicine (pp. 1079-1090). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-381422-7.10058-6

Regenerative Medicine of the Respiratory Tract. / Birchall, Martin A.; Janes, Sam; Macchiarini, Paolo.

Principles of Regenerative Medicine. Elsevier Inc., 2011. p. 1079-1090.

Research output: Chapter in Book/Report/Conference proceedingChapter

Birchall, MA, Janes, S & Macchiarini, P 2011, Regenerative Medicine of the Respiratory Tract. in Principles of Regenerative Medicine. Elsevier Inc., pp. 1079-1090. https://doi.org/10.1016/B978-0-12-381422-7.10058-6
Birchall MA, Janes S, Macchiarini P. Regenerative Medicine of the Respiratory Tract. In Principles of Regenerative Medicine. Elsevier Inc. 2011. p. 1079-1090 https://doi.org/10.1016/B978-0-12-381422-7.10058-6
Birchall, Martin A. ; Janes, Sam ; Macchiarini, Paolo. / Regenerative Medicine of the Respiratory Tract. Principles of Regenerative Medicine. Elsevier Inc., 2011. pp. 1079-1090
@inbook{799e6eaa4448489fb842245d1ec781fd,
title = "Regenerative Medicine of the Respiratory Tract",
abstract = "This chapter presents an overview of regenerative medicine of the respiratory tract. Olfactory ensheathing cells are a class of glial cells, which support regeneration of olfactory receptor neurons in the olfactory epithelium. When transplanted to other regions of the brain they may support regeneration of other classes of neurons. They also support axon regeneration and are successfully employed in rat models of spinal cord regeneration. Human nasal septum is a good source of chondrogenic cells with the potential to be used to engineer transplants for restorative surgery in otolaryngology. Partial laryngeal reconstruction is required for stenosis in children and adults and after resection of carcinomas in adults. Conventional means of restoring subglottic lumen include endoscopic techniques, which need repeating, large segmental resections, or the insertion of rib cartilage grafts. The synthetic or biological scaffolds may form the basis for myoblast progenitor cell proliferation and differentiation. The use of dynamic bioreactor {"}preconditioning{"} causes fiber-type differentiation into the appropriate MyHC subtypes (slow versus various forms of fast fibers) and, crucially, orientation of myotubes. The only curative treatment of any tracheal lesions involving less than 50{\%} of the total length of the trachea is achieved by segmental resection followed by tracheal mobilization and primary end-to-end anastomosis in adults and/or slide tracheoplasty in children with long-segment tracheal stenosis.",
author = "Birchall, {Martin A.} and Sam Janes and Paolo Macchiarini",
year = "2011",
doi = "10.1016/B978-0-12-381422-7.10058-6",
language = "English (US)",
isbn = "9780123814227",
pages = "1079--1090",
booktitle = "Principles of Regenerative Medicine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Regenerative Medicine of the Respiratory Tract

AU - Birchall, Martin A.

AU - Janes, Sam

AU - Macchiarini, Paolo

PY - 2011

Y1 - 2011

N2 - This chapter presents an overview of regenerative medicine of the respiratory tract. Olfactory ensheathing cells are a class of glial cells, which support regeneration of olfactory receptor neurons in the olfactory epithelium. When transplanted to other regions of the brain they may support regeneration of other classes of neurons. They also support axon regeneration and are successfully employed in rat models of spinal cord regeneration. Human nasal septum is a good source of chondrogenic cells with the potential to be used to engineer transplants for restorative surgery in otolaryngology. Partial laryngeal reconstruction is required for stenosis in children and adults and after resection of carcinomas in adults. Conventional means of restoring subglottic lumen include endoscopic techniques, which need repeating, large segmental resections, or the insertion of rib cartilage grafts. The synthetic or biological scaffolds may form the basis for myoblast progenitor cell proliferation and differentiation. The use of dynamic bioreactor "preconditioning" causes fiber-type differentiation into the appropriate MyHC subtypes (slow versus various forms of fast fibers) and, crucially, orientation of myotubes. The only curative treatment of any tracheal lesions involving less than 50% of the total length of the trachea is achieved by segmental resection followed by tracheal mobilization and primary end-to-end anastomosis in adults and/or slide tracheoplasty in children with long-segment tracheal stenosis.

AB - This chapter presents an overview of regenerative medicine of the respiratory tract. Olfactory ensheathing cells are a class of glial cells, which support regeneration of olfactory receptor neurons in the olfactory epithelium. When transplanted to other regions of the brain they may support regeneration of other classes of neurons. They also support axon regeneration and are successfully employed in rat models of spinal cord regeneration. Human nasal septum is a good source of chondrogenic cells with the potential to be used to engineer transplants for restorative surgery in otolaryngology. Partial laryngeal reconstruction is required for stenosis in children and adults and after resection of carcinomas in adults. Conventional means of restoring subglottic lumen include endoscopic techniques, which need repeating, large segmental resections, or the insertion of rib cartilage grafts. The synthetic or biological scaffolds may form the basis for myoblast progenitor cell proliferation and differentiation. The use of dynamic bioreactor "preconditioning" causes fiber-type differentiation into the appropriate MyHC subtypes (slow versus various forms of fast fibers) and, crucially, orientation of myotubes. The only curative treatment of any tracheal lesions involving less than 50% of the total length of the trachea is achieved by segmental resection followed by tracheal mobilization and primary end-to-end anastomosis in adults and/or slide tracheoplasty in children with long-segment tracheal stenosis.

UR - http://www.scopus.com/inward/record.url?scp=84882206271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882206271&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-381422-7.10058-6

DO - 10.1016/B978-0-12-381422-7.10058-6

M3 - Chapter

AN - SCOPUS:84882206271

SN - 9780123814227

SP - 1079

EP - 1090

BT - Principles of Regenerative Medicine

PB - Elsevier Inc.

ER -