TY - JOUR
T1 - Regenerative medicine as applied to solid organ transplantation
T2 - Current status and future challenges
AU - Orlando, Giuseppe
AU - Baptista, Pedro
AU - Birchall, Martin
AU - De Coppi, Paolo
AU - Farney, Alan
AU - Guimaraes-Souza, Nadia K.
AU - Opara, Emmanuel
AU - Rogers, Jeffrey
AU - Seliktar, Dror
AU - Shapira-Schweitzer, Keren
AU - Stratta, Robert J.
AU - Atala, Anthony
AU - Wood, Kathryn J.
AU - Soker, Shay
PY - 2011/3
Y1 - 2011/3
N2 - In the last two decades, regenerative medicine has shown the potential for "bench-to-bedside" translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were implanted without the reconstruction of the vascular supply, and the nutrients and oxygen were supplied by diffusion from adjacent tissues. Engineering of modular organs (namely, organs organized in functioning units referred to as modules and requiring the reconstruction of the vascular supply) is more complex and challenging. Models of functioning hearts and livers have been engineered using "natural tissue" scaffolds and efforts are underway to produce kidneys, pancreata and small intestine. Creation of custom-made bioengineered organs, where the cellular component is exquisitely autologous and have an internal vascular network, will theoretically overcome the two major hurdles in transplantation, namely the shortage of organs and the toxicity deriving from lifelong immunosuppression. This review describes recent advances in the engineering of several key tissues and organs. Transplant International
AB - In the last two decades, regenerative medicine has shown the potential for "bench-to-bedside" translational research in specific clinical settings. Progress made in cell and stem cell biology, material sciences and tissue engineering enabled researchers to develop cutting-edge technology which has lead to the creation of nonmodular tissue constructs such as skin, bladders, vessels and upper airways. In all cases, autologous cells were seeded on either artificial or natural supporting scaffolds. However, such constructs were implanted without the reconstruction of the vascular supply, and the nutrients and oxygen were supplied by diffusion from adjacent tissues. Engineering of modular organs (namely, organs organized in functioning units referred to as modules and requiring the reconstruction of the vascular supply) is more complex and challenging. Models of functioning hearts and livers have been engineered using "natural tissue" scaffolds and efforts are underway to produce kidneys, pancreata and small intestine. Creation of custom-made bioengineered organs, where the cellular component is exquisitely autologous and have an internal vascular network, will theoretically overcome the two major hurdles in transplantation, namely the shortage of organs and the toxicity deriving from lifelong immunosuppression. This review describes recent advances in the engineering of several key tissues and organs. Transplant International
KW - decellularization
KW - extracellular matrix
KW - regenerative medicine
KW - scaffold
KW - solid organ transplantation
KW - stem cells
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=79551525410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551525410&partnerID=8YFLogxK
U2 - 10.1111/j.1432-2277.2010.01182.x
DO - 10.1111/j.1432-2277.2010.01182.x
M3 - Article
C2 - 21062367
AN - SCOPUS:79551525410
VL - 24
SP - 223
EP - 232
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 3
ER -