Regeneration of rat sciatic nerve across a LactoSorb bioresorbable conduit with interposed short-segment nerve grafts

Paul C. Francel, Kevin S. Smith, F. Alan Stevens, Soon C. Kim, James Gossett, Cynthia Gossett, Mark E. Davis, Marc E Lenaerts, Paul Tompkins

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Object. This study was conducted to evaluate peripheral nerve regeneration through a conduit composed of a bioresorbable material (LactoSorb). Methods. Sprague-Dawley rats weighing approximately 250 g were randomized into five groups. A 20-mm-long sciatic nerve gap was created, then it was bridged by a reverse nerve autograft (Group I), an empty silicone tube (Group II), a silicone tube containing a short (2-mm) interposed nerve segment (Group III), an empty LactoSorb conduit (Group IV), or a LactoSorb conduit containing a 2-mm interposed nerve segment (Group V). The intact sciatic nerve served as the control in each animal. At 16 weeks postoperatively, no nerve regeneration was observed through either the empty silicone tube or the empty LactoSorb conduit. There was regeneration in all animals receiving the reverse autograft as well as in all animals receiving the silicone or LactoSorb conduit containing the 2-mm interposed nerve segment. Effective regeneration was assessed based on histological, electrophysiological, and morphometric criteria. Conclusions. The results indicate that a conduit made of resorbable material will support sciatic nerve regeneration over a critical gap defect.

Original languageEnglish (US)
Pages (from-to)549-554
Number of pages6
JournalJournal of Neurosurgery
Volume99
Issue number3
StatePublished - Sep 1 2003
Externally publishedYes

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Keywords

  • Bioresorbable conduit
  • Electrophysiological study
  • Morphometric study
  • Nerve graft
  • Nerve regeneration
  • Rat

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Francel, P. C., Smith, K. S., Stevens, F. A., Kim, S. C., Gossett, J., Gossett, C., Davis, M. E., Lenaerts, M. E., & Tompkins, P. (2003). Regeneration of rat sciatic nerve across a LactoSorb bioresorbable conduit with interposed short-segment nerve grafts. Journal of Neurosurgery, 99(3), 549-554.