TY - JOUR
T1 - Regeneration after nerve transection
T2 - Effect of inhibition of collagen synthesis
AU - Pleasure, David E
AU - William Bora, F.
AU - Lane, Joseph
AU - Prockop, Darwin
PY - 1974
Y1 - 1974
N2 - Dense collagen scar forms at the cut ends of transected nerves, and impedes nerve regeneration. To minimize scarring, we treated rats with the proline analog, cis-hydroxyproline, from day 4 to 21 after sciatic nerve transection and reanastomosis. Twenty-eight days after surgery, there was 47% less collagen in the distal nerve stump of treated rats than of controls. Seventy days after surgery, posterior tibial nerve content of the myelin lipids, sulfatide, and unesterified cholesterol, was 40% higher in treated rats than in controls.
AB - Dense collagen scar forms at the cut ends of transected nerves, and impedes nerve regeneration. To minimize scarring, we treated rats with the proline analog, cis-hydroxyproline, from day 4 to 21 after sciatic nerve transection and reanastomosis. Twenty-eight days after surgery, there was 47% less collagen in the distal nerve stump of treated rats than of controls. Seventy days after surgery, posterior tibial nerve content of the myelin lipids, sulfatide, and unesterified cholesterol, was 40% higher in treated rats than in controls.
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U2 - 10.1016/0014-4886(74)90101-0
DO - 10.1016/0014-4886(74)90101-0
M3 - Article
C2 - 4415515
AN - SCOPUS:0016295995
VL - 45
SP - 72
EP - 78
JO - Neurodegeneration
JF - Neurodegeneration
SN - 0014-4886
IS - 1
ER -