Regenerating Mandibular Bone Using rhBMP-2

Part 2-Treatment of Chronic, Defect Non-Union Fractures

Frank J Verstraete, Boaz Arzi, Daniel J. Huey, Derek Cissell, Kyriacos A. Athanasiou

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To describe a surgical technique using a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures. Study Design: Case series. Animals: Dogs (n=6) that had internal fixation of defect non-union mandibular fracture. Methods: In 5 dogs, the repair was staged and extraction of teeth performed during the initial procedure. After 21-98 days (mean, 27 days) pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate was contoured and secured to the mandible. A compression resistant matrix (CRM) infused with rhBMP-2 was implanted in the defect. The implant was then covered with a soft tissue envelope followed by surgical wound closure. Results: All dogs healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings in 1 dog at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome. Conclusion: Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.

Original languageEnglish (US)
Pages (from-to)410-416
Number of pages7
JournalVeterinary Surgery
Volume44
Issue number4
DOIs
StatePublished - May 1 2015

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Mandibular Fractures
bones
Dogs
Bone and Bones
dogs
Jaw Fixation Techniques
Mandibular Reconstruction
Therapeutics
Tooth Extraction
mandible (bone)
titanium
Porosity
bone density
Titanium
bone formation
Mandible
Intubation
Osteogenesis
animal injuries
Bone Density

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Regenerating Mandibular Bone Using rhBMP-2 : Part 2-Treatment of Chronic, Defect Non-Union Fractures. / Verstraete, Frank J; Arzi, Boaz; Huey, Daniel J.; Cissell, Derek; Athanasiou, Kyriacos A.

In: Veterinary Surgery, Vol. 44, No. 4, 01.05.2015, p. 410-416.

Research output: Contribution to journalArticle

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