Abstract
Objective: To describe a surgical technique using a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures. Study Design: Case series. Animals: Dogs (n=6) that had internal fixation of defect non-union mandibular fracture. Methods: In 5 dogs, the repair was staged and extraction of teeth performed during the initial procedure. After 21-98 days (mean, 27 days) pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate was contoured and secured to the mandible. A compression resistant matrix (CRM) infused with rhBMP-2 was implanted in the defect. The implant was then covered with a soft tissue envelope followed by surgical wound closure. Results: All dogs healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings in 1 dog at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome. Conclusion: Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 410-416 |
| Number of pages | 7 |
| Journal | Veterinary Surgery |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2015 |
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ASJC Scopus subject areas
- veterinary(all)
Cite this
Regenerating Mandibular Bone Using rhBMP-2 : Part 2-Treatment of Chronic, Defect Non-Union Fractures. / Verstraete, Frank J; Arzi, Boaz; Huey, Daniel J.; Cissell, Derek; Athanasiou, Kyriacos A.
In: Veterinary Surgery, Vol. 44, No. 4, 01.05.2015, p. 410-416.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regenerating Mandibular Bone Using rhBMP-2
T2 - Part 2-Treatment of Chronic, Defect Non-Union Fractures
AU - Verstraete, Frank J
AU - Arzi, Boaz
AU - Huey, Daniel J.
AU - Cissell, Derek
AU - Athanasiou, Kyriacos A.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objective: To describe a surgical technique using a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures. Study Design: Case series. Animals: Dogs (n=6) that had internal fixation of defect non-union mandibular fracture. Methods: In 5 dogs, the repair was staged and extraction of teeth performed during the initial procedure. After 21-98 days (mean, 27 days) pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate was contoured and secured to the mandible. A compression resistant matrix (CRM) infused with rhBMP-2 was implanted in the defect. The implant was then covered with a soft tissue envelope followed by surgical wound closure. Results: All dogs healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings in 1 dog at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome. Conclusion: Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.
AB - Objective: To describe a surgical technique using a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures. Study Design: Case series. Animals: Dogs (n=6) that had internal fixation of defect non-union mandibular fracture. Methods: In 5 dogs, the repair was staged and extraction of teeth performed during the initial procedure. After 21-98 days (mean, 27 days) pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate was contoured and secured to the mandible. A compression resistant matrix (CRM) infused with rhBMP-2 was implanted in the defect. The implant was then covered with a soft tissue envelope followed by surgical wound closure. Results: All dogs healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. CT findings in 1 dog at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome. Conclusion: Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.
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U2 - 10.1111/j.1532-950X.2014.12122.x
DO - 10.1111/j.1532-950X.2014.12122.x
M3 - Article
VL - 44
SP - 410
EP - 416
JO - Veterinary Surgery
JF - Veterinary Surgery
SN - 0161-3499
IS - 4
ER -