Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle

D. M. Rotto, Charles L Stebbins, Marc P Kaufman

Research output: Contribution to journalArticle

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Abstract

Static exercise increases arterial pressure, heart rate, and ventilation, effects which are believed in part to arise reflexly from a metabolic stimulus in the working muscle. In anesthetized cats, we tested the hypothesis that intra-arterial injections of lactic and hydrochloric acid, which created levels of these substances in muscle similar to those seen during contraction, reflexly increased cardiovascular and ventilatory function. Hydrochloric acid (32 and 57 mM; 1 ml) injected into the arterial supply of the triceps surae decreased intramuscular pH from 7.26 ± 0.05 to 7.17 ± 0.05 (P < 0.01) and reflexly increased arterial pressure (23 ± 7 mmHg; P < 0.01), heart rate (11 ± 2 beats/min; P < 0.001), and ventilation (187 ± 72 ml/min; P < 0.05). Static contraction of the triceps surae decreased intramuscular pH from 7.28 ± 0.06 to 7.13 ± 0.06 (P < 0.01). Lactic acid was more potent in causing reflexes than was equimolar HCl. For example, lactic acid containing 4 mM lactate and 0.87 mM H+ reflexly increased arterial pressure, heart rate, and ventilation, whereas 0.87 mM HCl did not. Intra-arterial sodium lactate (13 and 33 mM) at a neutral pH had no effect on these variables. We conclude that contraction-induced accumulation of H+, especially that arising from lactic acid, might provide a metabolic stimulus to evoke reflex autonomic effects.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalJournal of Applied Physiology
Volume67
Issue number1
StatePublished - 1989

Fingerprint

Hindlimb
Reflex
Lactic Acid
Cats
Muscles
Ventilation
Arterial Pressure
Hydrochloric Acid
Heart Rate
Sodium Lactate
Autonomic Agents
Intra-Arterial Injections

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Reflex cardiovascular and ventilatory responses to increasing H+ activity in cat hindlimb muscle. / Rotto, D. M.; Stebbins, Charles L; Kaufman, Marc P.

In: Journal of Applied Physiology, Vol. 67, No. 1, 1989, p. 256-263.

Research output: Contribution to journalArticle

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