TY - JOUR
T1 - Reevaluation of the evolutionary events within recA/RAD51 phylogeny
AU - Chintapalli, Sree V.
AU - Bhardwaj, Gaurav
AU - Babu, Jagadish
AU - Hadjiyianni, Loukia
AU - Hong, Yoojin
AU - Todd, George K.
AU - Boosalis, Casey A.
AU - Zhang, Zhenhai
AU - Zhou, Xiaofan
AU - Ma, Hong
AU - Anishkin, Andriy
AU - van Rossum, Damian B.
AU - Patterson, Randen L.
PY - 2013/4/10
Y1 - 2013/4/10
N2 - Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.
AB - Background: The recA/RAD51 gene family encodes a diverse set of recombinase proteins that affect homologous recombination, DNA-repair, and genome stability. The recA gene family is expressed across all three domains of life - Eubacteria, Archaea, and Eukaryotes - and even in some viruses. To date, efforts to resolve the deep evolutionary origins of this ancient protein family have been hindered by the high sequence divergence between paralogous groups (i.e. ~30% average pairwise identity).Results: Through large taxon sampling and the use of a phylogenetic algorithm designed for inferring evolutionary events in highly divergent paralogs, we obtained a robust, parsimonious and more refined phylogenetic history of the recA/RAD51 superfamily.Conclusions: In summary, our model for the evolution of recA/RAD51 family provides a better understanding of the ancient origin of recA proteins and the multiple events that lead to the diversification of recA homologs in eukaryotes, including the discovery of additional RAD51 sub-families.
KW - Phylogenetic inference
KW - RAD51
KW - recA
KW - Recombinase
UR - http://www.scopus.com/inward/record.url?scp=84875946720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875946720&partnerID=8YFLogxK
U2 - 10.1186/1471-2164-14-240
DO - 10.1186/1471-2164-14-240
M3 - Article
C2 - 23574621
AN - SCOPUS:84875946720
VL - 14
JO - BMC Genomics
JF - BMC Genomics
SN - 1471-2164
IS - 1
M1 - 240
ER -