Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as α3β1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that α3β1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of β1 integrin in a reelin-dependent manner. Thus, α3β1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.
- Cerebral cortex
- Neuronal migration
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience