Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease

Mark B. Schapiro, Pietro Pietrini, Cheryl L. Grady, M. J. Ball, Charles DeCarli, Anand Kumar, Jeffrey A. Kaye, James V. Haxby

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume56
Issue number8
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Alzheimer Disease
Dementia
Glucose
Parietal Lobe
Temporal Lobe
Parkinson Disease
Neocortex
Fluorodeoxyglucose F18
Motor Cortex
Positron-Emission Tomography

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease. / Schapiro, Mark B.; Pietrini, Pietro; Grady, Cheryl L.; Ball, M. J.; DeCarli, Charles; Kumar, Anand; Kaye, Jeffrey A.; Haxby, James V.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 56, No. 8, 1993, p. 859-864.

Research output: Contribution to journalArticle

Schapiro, Mark B. ; Pietrini, Pietro ; Grady, Cheryl L. ; Ball, M. J. ; DeCarli, Charles ; Kumar, Anand ; Kaye, Jeffrey A. ; Haxby, James V. / Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease. In: Journal of Neurology, Neurosurgery and Psychiatry. 1993 ; Vol. 56, No. 8. pp. 859-864.
@article{860fefed1b534b09a9b62e6df656539f,
title = "Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease",
abstract = "Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.",
author = "Schapiro, {Mark B.} and Pietro Pietrini and Grady, {Cheryl L.} and Ball, {M. J.} and Charles DeCarli and Anand Kumar and Kaye, {Jeffrey A.} and Haxby, {James V.}",
year = "1993",
doi = "10.1136/jnnp.56.8.859",
language = "English (US)",
volume = "56",
pages = "859--864",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "8",

}

TY - JOUR

T1 - Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease

AU - Schapiro, Mark B.

AU - Pietrini, Pietro

AU - Grady, Cheryl L.

AU - Ball, M. J.

AU - DeCarli, Charles

AU - Kumar, Anand

AU - Kaye, Jeffrey A.

AU - Haxby, James V.

PY - 1993

Y1 - 1993

N2 - Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.

AB - Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.

UR - http://www.scopus.com/inward/record.url?scp=0027303174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027303174&partnerID=8YFLogxK

U2 - 10.1136/jnnp.56.8.859

DO - 10.1136/jnnp.56.8.859

M3 - Article

C2 - 8350100

AN - SCOPUS:0027303174

VL - 56

SP - 859

EP - 864

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 8

ER -