Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus)

Amanda J. Palumbo, Michael S. Denison, Serge I. Doroshov, Ronald S. Tjeerdema

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Migrating white sturgeon (Acipenser transmontamus) may be subject to agricultural, municipal, and industrial wastewater effluents that likely contain different classes of endocrine-disrupting contaminants. Concern is mounting about the negative effects of environmental estrogens on fish reproduction; however, in environmental mixtures, the affects from estrogenic compounds may be suppressed by aryl hydrocarbon receptor (AhR) ligands. Indeed, reductions in 17β-estradiol-induced (0.01 and 1 mg/kg) vitellogenin (VTG) levels were observed in white sturgeon coinjected with β-naphthoflavone (BNF; 50 mg/kg), a model for contaminants that activate the AhR. Variation in the time of injection was used to attempt to correlate VTG inhibition to ethoxyresorufin-O-deethylase activity. No evidence was found to suggest that the inhibition of VTG is a direct result of enhanced estrogen metabolism by BNF-induced enzymes. Results of the present study are relevant for monitoring programs that measure VTG, because these results show that AhR-active environmental contaminants can repress VTG synthesis, which commonly is used as an indicator of estrogen-mimicking contaminants. Furthermore, suppression of natural estrogen signaling by AhR agonists may have significant effects on fish reproduction.

Original languageEnglish (US)
Pages (from-to)1749-1755
Number of pages7
JournalEnvironmental Toxicology and Chemistry
Volume28
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Vitellogenins
Aryl Hydrocarbon Receptors
Estrogens
hydrocarbon
pollutant
Impurities
Fish
Reproduction
estrogenic compound
Fishes
fish
Cytochrome P-450 CYP1A1
ligand
Waste Water
Mountings
Metabolism
metabolism
enzyme
effluent
Effluents

Keywords

  • Antiestrogen
  • Aryl hydrocarbon receptor
  • Endocrine disruption
  • Sturgeon
  • Vitellogenin

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Environmental Chemistry

Cite this

Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus). / Palumbo, Amanda J.; Denison, Michael S.; Doroshov, Serge I.; Tjeerdema, Ronald S.

In: Environmental Toxicology and Chemistry, Vol. 28, No. 8, 08.2009, p. 1749-1755.

Research output: Contribution to journalArticle

Palumbo, Amanda J. ; Denison, Michael S. ; Doroshov, Serge I. ; Tjeerdema, Ronald S. / Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser transmontamus). In: Environmental Toxicology and Chemistry. 2009 ; Vol. 28, No. 8. pp. 1749-1755.
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