Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman, Robert F Berman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

Original languageEnglish (US)
Pages (from-to)1061-1065
Number of pages5
JournalPeptides
Volume5
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Melanocyte-Stimulating Hormones
Blood-Brain Barrier
Permeation
Anticonvulsants
Adrenocorticotropic Hormone
Rats
Epilepsy
Animals
Seizures
Animal Models
Org 2766

Keywords

  • ACTH/MSH analog
  • Amygdala
  • Animal model
  • Blood-brain barrier
  • EEG
  • Infantile spasms
  • Kindling
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH. / Goldman, Harold; Berman, Robert F.

In: Peptides, Vol. 5, No. 6, 1984, p. 1061-1065.

Research output: Contribution to journalArticle

Goldman, Harold ; Berman, Robert F. / Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH. In: Peptides. 1984 ; Vol. 5, No. 6. pp. 1061-1065.
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