Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman; Robert F Berman

doi:10.1016/0196-9781(84)90171-2

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman, Robert F Berman

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

Original language	English (US)
Pages (from-to)	1061-1065
Number of pages	5
Journal	Peptides
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(84)90171-2
State	Published - 1984
Externally published	Yes

Keywords

ACTH/MSH analog
Amygdala
Animal model
Blood-brain barrier
EEG
Infantile spasms
Kindling
Seizures

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(84)90171-2

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abstract = "A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.",

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AU - Goldman, Harold

AU - Berman, Robert F

PY - 1984

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AB - A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

KW - ACTH/MSH analog

KW - Amygdala

KW - Animal model

KW - Blood-brain barrier

KW - EEG

KW - Infantile spasms

KW - Kindling

KW - Seizures

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JO - Peptides

JF - Peptides

SN - 0196-9781

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ER -

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Abstract

Keywords

ASJC Scopus subject areas

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