Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman; Robert F Berman

doi:10.1016/0196-9781(84)90171-2

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman, Robert F Berman

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

Original language	English (US)
Pages (from-to)	1061-1065
Number of pages	5
Journal	Peptides
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(84)90171-2
State	Published - 1984
Externally published	Yes

Keywords

ACTH/MSH analog
Amygdala
Animal model
Blood-brain barrier
EEG
Infantile spasms
Kindling
Seizures

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0196-9781(84)90171-2

Cite this

@article{8bf01000a44047c68223f6af9723fabe,

title = "Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH",

abstract = "A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.",

keywords = "ACTH/MSH analog, Amygdala, Animal model, Blood-brain barrier, EEG, Infantile spasms, Kindling, Seizures",

author = "Harold Goldman and Berman, {Robert F}",

year = "1984",

doi = "10.1016/0196-9781(84)90171-2",

language = "English (US)",

volume = "5",

pages = "1061--1065",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

AU - Goldman, Harold

AU - Berman, Robert F

PY - 1984

Y1 - 1984

N2 - A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

AB - A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

KW - ACTH/MSH analog

KW - Amygdala

KW - Animal model

KW - Blood-brain barrier

KW - EEG

KW - Infantile spasms

KW - Kindling

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=0021741342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021741342&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(84)90171-2

DO - 10.1016/0196-9781(84)90171-2

M3 - Article

C2 - 6099557

AN - SCOPUS:0021741342

VL - 5

SP - 1061

EP - 1065

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 6

ER -

Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this