Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH

Harold Goldman, Robert F Berman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.

Original languageEnglish (US)
Pages (from-to)1061-1065
Number of pages5
JournalPeptides
Volume5
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

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Keywords

  • ACTH/MSH analog
  • Amygdala
  • Animal model
  • Blood-brain barrier
  • EEG
  • Infantile spasms
  • Kindling
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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