Abstract
A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1061-1065 |
| Number of pages | 5 |
| Journal | Peptides |
| Volume | 5 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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Keywords
- ACTH/MSH analog
- Amygdala
- Animal model
- Blood-brain barrier
- EEG
- Infantile spasms
- Kindling
- Seizures
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH. / Goldman, Harold; Berman, Robert F.
In: Peptides, Vol. 5, No. 6, 1984, p. 1061-1065.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH
AU - Goldman, Harold
AU - Berman, Robert F
PY - 1984
Y1 - 1984
N2 - A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
AB - A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
KW - ACTH/MSH analog
KW - Amygdala
KW - Animal model
KW - Blood-brain barrier
KW - EEG
KW - Infantile spasms
KW - Kindling
KW - Seizures
UR - http://www.scopus.com/inward/record.url?scp=0021741342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021741342&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(84)90171-2
DO - 10.1016/0196-9781(84)90171-2
M3 - Article
VL - 5
SP - 1061
EP - 1065
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 6
ER -