Abstract
A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy-the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
Original language | English (US) |
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Pages (from-to) | 1061-1065 |
Number of pages | 5 |
Journal | Peptides |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - 1984 |
Externally published | Yes |
Keywords
- ACTH/MSH analog
- Amygdala
- Animal model
- Blood-brain barrier
- EEG
- Infantile spasms
- Kindling
- Seizures
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience