Reduction in pancreatic protein and amylase content after intraductal 5-azacytidine and cycloheximide

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The protein content of fasted rat pancreas was 120 ± 4 (mean ± standard deviation) mg./gm. tissue wet weight (T.W.W.); the amylase content was 17143 ± 3765 units/gm. T.W.W. Intraductal administration of normal saline after 1 hour (114 ± 6), 4 hours (111 ± 9) or 24 hours (118 ± 11) had no significant (p>0.05) effect on the pancreatic protein or amylase (15719 ± 2217, 14203 ± 1990, 15581 ± 2070, units/gm. T.W.W.) content of the rat pancreas. Intraductal administration of 5-azacytidine after 4 and 24 hours, significantly (p <0.001) reduced the pancreatic protein and amylase content. Cycloheximide had similar effect on the pancreatic protein and amylase content. Inhibition of protein synthesis may be the mechanism of protective effect of cycloheximide and 5-azacytidine on acute experimental pancreatitis.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Proctology Gastroenterology and Colon and Rectal Surgery
Pages7-10
Number of pages4
Volume32
Edition11
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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