Purpose: To determine the change in intraocular pressure (IOP) after cataract extraction in the observation group of the Ocular Hypertension Treatment Study. Design: Comparative case series. Participants: Forty-two participants (63 eyes) who underwent cataract surgery in at least 1 eye during the study and a control group of 743 participants (743 eyes) who did not undergo cataract surgery. Methods: We defined the "split date" as the study visit date at which cataract surgery was reported in the cataract surgery group and a corresponding date in the control group. Preoperative IOP was defined as the mean IOP of up to 3 visits before the split date. Postoperative IOP was the mean IOP of up to 3 visits including the split date (0, 6, and 12 months' with "0 months" equaling the split date). In both groups, we censored data after initiation of ocular hypotensive medication or glaucoma surgery of any kind. Main Outcome Measures: Difference in preoperative and postoperative IOP. Results: In the cataract group, postoperative IOP was significantly lower than the preoperative IOP (19.8±3.2 mmHg vs. 23.9±3.2 mmHg; P<0.001). The postoperative IOP remained lower than the preoperative IOP for at least 36 months. The average decrease in postoperative IOP from preoperative IOP was 16.5%, and 39.7% of eyes had postoperative IOP <20% below preoperative IOP. A greater reduction in postoperative IOP occurred in the eyes with the highest preoperative IOP. In the control group, the corresponding mean IOPs were 23.8±3.6 before the split date and 23.4±3.9 after the split date. Conclusions: Cataract surgery decreases IOP in patients with ocular hypertension over a long period of time. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
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