Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy

The Cardiovascular Health Study

P. L. Enright, R. A. Kronmal, V. E. Smith, J. M. Gardin, Marc B Schenker, T. A. Manolio

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The Cardiovascular Health Study provided the opportunity to determine the association of subclinical and clinical cardiovascular disease with pulmonary function in a population sample of elderly adults. Included were 2,955 women and 2,246 men over age 64 years who were recruited for this observational study from four communities and completed extensive examinations that included spirometry, echocardiograms, and blood pressure. Current smokers, past smokers with >20 pack-years of smoking, and persons with a history of asthma, chronic bronchitis, or emphysema were excluded from this analysis, leaving 2,784 (55%) of the cohort. Systolic hypertension or coronary artery disease was associated with 40- to 100-mL decrements in FEV1 and 50- to 150- mL decrements in FVC, while a history of congestive heart failure was associated with 200 to 300 mL lower FEV1 and FVC values (p<0.0001), after correcting for age, height, and waist size. Higher left ventricular (LV) mass was also significantly associated with a decrease in FEV1 and FVC in multivariate models. This relationship was strongest with the end-diastolic LV posterior wall thickness component of LV mass. In summary, FEV1 and FVC arc reduced in elderly persons with hypertension, ischemic heart disease, higher LV mass, and congestive heart failure, though the magnitude of these associations is relatively small unless heart failure supervenes. Substantial decrements in percent predicted FEV1 and FVC should not be attributed to the presence of uncomplicated ischemic heart disease or hypertension alone.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalChest
Volume107
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Vital Capacity
Left Ventricular Hypertrophy
Coronary Disease
Heart Failure
Hypertension
Myocardial Ischemia
Health
Spirometry
Chronic Bronchitis
Emphysema
Observational Studies
Coronary Artery Disease
Cardiovascular Diseases
Asthma
Smoking
Blood Pressure
Lung
Population

Keywords

  • congestive heart failure
  • echocardiography
  • heart-lung interactions
  • left ventricular mass
  • pulmonary function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy : The Cardiovascular Health Study. / Enright, P. L.; Kronmal, R. A.; Smith, V. E.; Gardin, J. M.; Schenker, Marc B; Manolio, T. A.

In: Chest, Vol. 107, No. 1, 1995, p. 28-35.

Research output: Contribution to journalArticle

Enright, P. L. ; Kronmal, R. A. ; Smith, V. E. ; Gardin, J. M. ; Schenker, Marc B ; Manolio, T. A. / Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy : The Cardiovascular Health Study. In: Chest. 1995 ; Vol. 107, No. 1. pp. 28-35.
@article{ecb515c274fb419ab5bfdf6066d2e5f3,
title = "Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy: The Cardiovascular Health Study",
abstract = "The Cardiovascular Health Study provided the opportunity to determine the association of subclinical and clinical cardiovascular disease with pulmonary function in a population sample of elderly adults. Included were 2,955 women and 2,246 men over age 64 years who were recruited for this observational study from four communities and completed extensive examinations that included spirometry, echocardiograms, and blood pressure. Current smokers, past smokers with >20 pack-years of smoking, and persons with a history of asthma, chronic bronchitis, or emphysema were excluded from this analysis, leaving 2,784 (55{\%}) of the cohort. Systolic hypertension or coronary artery disease was associated with 40- to 100-mL decrements in FEV1 and 50- to 150- mL decrements in FVC, while a history of congestive heart failure was associated with 200 to 300 mL lower FEV1 and FVC values (p<0.0001), after correcting for age, height, and waist size. Higher left ventricular (LV) mass was also significantly associated with a decrease in FEV1 and FVC in multivariate models. This relationship was strongest with the end-diastolic LV posterior wall thickness component of LV mass. In summary, FEV1 and FVC arc reduced in elderly persons with hypertension, ischemic heart disease, higher LV mass, and congestive heart failure, though the magnitude of these associations is relatively small unless heart failure supervenes. Substantial decrements in percent predicted FEV1 and FVC should not be attributed to the presence of uncomplicated ischemic heart disease or hypertension alone.",
keywords = "congestive heart failure, echocardiography, heart-lung interactions, left ventricular mass, pulmonary function",
author = "Enright, {P. L.} and Kronmal, {R. A.} and Smith, {V. E.} and Gardin, {J. M.} and Schenker, {Marc B} and Manolio, {T. A.}",
year = "1995",
language = "English (US)",
volume = "107",
pages = "28--35",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "1",

}

TY - JOUR

T1 - Reduced vital capacity in elderly persons with hypertension, coronary heart disease, or left ventricular hypertrophy

T2 - The Cardiovascular Health Study

AU - Enright, P. L.

AU - Kronmal, R. A.

AU - Smith, V. E.

AU - Gardin, J. M.

AU - Schenker, Marc B

AU - Manolio, T. A.

PY - 1995

Y1 - 1995

N2 - The Cardiovascular Health Study provided the opportunity to determine the association of subclinical and clinical cardiovascular disease with pulmonary function in a population sample of elderly adults. Included were 2,955 women and 2,246 men over age 64 years who were recruited for this observational study from four communities and completed extensive examinations that included spirometry, echocardiograms, and blood pressure. Current smokers, past smokers with >20 pack-years of smoking, and persons with a history of asthma, chronic bronchitis, or emphysema were excluded from this analysis, leaving 2,784 (55%) of the cohort. Systolic hypertension or coronary artery disease was associated with 40- to 100-mL decrements in FEV1 and 50- to 150- mL decrements in FVC, while a history of congestive heart failure was associated with 200 to 300 mL lower FEV1 and FVC values (p<0.0001), after correcting for age, height, and waist size. Higher left ventricular (LV) mass was also significantly associated with a decrease in FEV1 and FVC in multivariate models. This relationship was strongest with the end-diastolic LV posterior wall thickness component of LV mass. In summary, FEV1 and FVC arc reduced in elderly persons with hypertension, ischemic heart disease, higher LV mass, and congestive heart failure, though the magnitude of these associations is relatively small unless heart failure supervenes. Substantial decrements in percent predicted FEV1 and FVC should not be attributed to the presence of uncomplicated ischemic heart disease or hypertension alone.

AB - The Cardiovascular Health Study provided the opportunity to determine the association of subclinical and clinical cardiovascular disease with pulmonary function in a population sample of elderly adults. Included were 2,955 women and 2,246 men over age 64 years who were recruited for this observational study from four communities and completed extensive examinations that included spirometry, echocardiograms, and blood pressure. Current smokers, past smokers with >20 pack-years of smoking, and persons with a history of asthma, chronic bronchitis, or emphysema were excluded from this analysis, leaving 2,784 (55%) of the cohort. Systolic hypertension or coronary artery disease was associated with 40- to 100-mL decrements in FEV1 and 50- to 150- mL decrements in FVC, while a history of congestive heart failure was associated with 200 to 300 mL lower FEV1 and FVC values (p<0.0001), after correcting for age, height, and waist size. Higher left ventricular (LV) mass was also significantly associated with a decrease in FEV1 and FVC in multivariate models. This relationship was strongest with the end-diastolic LV posterior wall thickness component of LV mass. In summary, FEV1 and FVC arc reduced in elderly persons with hypertension, ischemic heart disease, higher LV mass, and congestive heart failure, though the magnitude of these associations is relatively small unless heart failure supervenes. Substantial decrements in percent predicted FEV1 and FVC should not be attributed to the presence of uncomplicated ischemic heart disease or hypertension alone.

KW - congestive heart failure

KW - echocardiography

KW - heart-lung interactions

KW - left ventricular mass

KW - pulmonary function

UR - http://www.scopus.com/inward/record.url?scp=0028872966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028872966&partnerID=8YFLogxK

M3 - Article

VL - 107

SP - 28

EP - 35

JO - Chest

JF - Chest

SN - 0012-3692

IS - 1

ER -