Reduced ultrasonic vocalizations in vasopressin 1b knockout mice

M. L. Scattoni, H. G. McFarlane, V. Zhodzishsky, H. K. Caldwell, W. S. Young, L. Ricceri, Jacqueline Crawley

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The neuropeptides oxytocin and vasopressin have been implicated in rodent social and affiliative behaviors, including social bonding, parental care, social recognition, social memory, vocalizations, territoriality, and aggression, as well as components of human social behaviors and the etiology of autism. Previous investigations of mice with various manipulations of the oxytocin and vasopressin systems reported unusual levels of ultrasonic vocalizations in social settings. We employed a vasopressin 1b receptor (Avpr1b) knockout mouse to evaluate the role of the vasopressin 1b receptor subtype in the emission of ultrasonic vocalizations in adult and infant mice. Avpr1b null mutant female mice emitted fewer ultrasonic vocalizations, and their vocalizations were generally at lower frequencies, during a resident-intruder test. Avpr1b null mutant pups emitted ultrasonic vocalizations similar to heterozygote and wildtype littermates when separated from the nest on postnatal days 3, 6, 9, and 12. However, maternal potentiation of ultrasonic vocalizations in Avpr1b null and heterozygote mutants was absent, when tested at postnatal day 9. These results indicate that Avpr1b null mutant mice are impaired in the modulation of ultrasonic vocalizations within different social contexts at infant and adult ages.

Original languageEnglish (US)
Pages (from-to)371-378
Number of pages8
JournalBehavioural Brain Research
Volume187
Issue number2
DOIs
StatePublished - Mar 5 2008
Externally publishedYes

Fingerprint

Vasopressin Receptors
Vasopressins
Knockout Mice
Ultrasonics
Oxytocin
Heterozygote
Territoriality
Social Behavior
Autistic Disorder
Neuropeptides
Aggression
Rodentia
Mothers

Keywords

  • Autistic spectrum disorders
  • Female-female mouse interactions
  • Maternal potentiation
  • Mouse models
  • Nest odor orientation
  • Social recognition

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Scattoni, M. L., McFarlane, H. G., Zhodzishsky, V., Caldwell, H. K., Young, W. S., Ricceri, L., & Crawley, J. (2008). Reduced ultrasonic vocalizations in vasopressin 1b knockout mice. Behavioural Brain Research, 187(2), 371-378. https://doi.org/10.1016/j.bbr.2007.09.034

Reduced ultrasonic vocalizations in vasopressin 1b knockout mice. / Scattoni, M. L.; McFarlane, H. G.; Zhodzishsky, V.; Caldwell, H. K.; Young, W. S.; Ricceri, L.; Crawley, Jacqueline.

In: Behavioural Brain Research, Vol. 187, No. 2, 05.03.2008, p. 371-378.

Research output: Contribution to journalArticle

Scattoni, ML, McFarlane, HG, Zhodzishsky, V, Caldwell, HK, Young, WS, Ricceri, L & Crawley, J 2008, 'Reduced ultrasonic vocalizations in vasopressin 1b knockout mice', Behavioural Brain Research, vol. 187, no. 2, pp. 371-378. https://doi.org/10.1016/j.bbr.2007.09.034
Scattoni ML, McFarlane HG, Zhodzishsky V, Caldwell HK, Young WS, Ricceri L et al. Reduced ultrasonic vocalizations in vasopressin 1b knockout mice. Behavioural Brain Research. 2008 Mar 5;187(2):371-378. https://doi.org/10.1016/j.bbr.2007.09.034
Scattoni, M. L. ; McFarlane, H. G. ; Zhodzishsky, V. ; Caldwell, H. K. ; Young, W. S. ; Ricceri, L. ; Crawley, Jacqueline. / Reduced ultrasonic vocalizations in vasopressin 1b knockout mice. In: Behavioural Brain Research. 2008 ; Vol. 187, No. 2. pp. 371-378.
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