Reduced temporal lobe glucose metabolism in aging

J. L. Eberling, Thomas E Nordahl, N. Kusubov, Bruce R Reed, T. F. Budinger, W. J. Jagust

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The results of a positron emission tomography study of regional cerebral metabolic rates for glucose are reported for 8 healthy old subjects (mean age, 66 yr; standard deviation [SD], 5) and 9 young subjects (mean age, 27 yr; SD, 4.6) using a high resolution positron emission tomograph and the glucose metabolic tracer 18F-fluorodeoxyglucose. Older subjects showed significantly lower cerebral metabolic rates than did the young subjects, in anterior, middle, and posterior temporal neocortex and in mesial temporal cortex, with the largest differences occurring in anterior temporal cortex (temporal pole). The current findings may reflect either de creases in regional cerebral metabolic rates for glucose that occur with normal aging, or early indications of cognitive dysfunction that is associated with age related disorders.

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalJournal of Neuroimaging
Volume5
Issue number3
StatePublished - 1995

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

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    Eberling, J. L., Nordahl, T. E., Kusubov, N., Reed, B. R., Budinger, T. F., & Jagust, W. J. (1995). Reduced temporal lobe glucose metabolism in aging. Journal of Neuroimaging, 5(3), 178-182.