Reduced lean mass in early Alzheimer disease and its association with brain atrophy

Jeffrey M. Burns, David K Johnson, Amber Watts, Russell H. Swerdlow, William M. Brooks

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Objective: To examine body composition in individuals with early AD and without dementia and its relation to cognition and brain volume. Design: Cross-sectional case-control study. Participants: Individuals without dementia (Clinical Dementia Rating, 0; n=70) and with early-stage AD (Clinical Dementia Rating, 0.5 or 1; n=70) in the Alzheimer and Memory Program at the University of Kansas School of Medicine. Main Outcome Measures: Participants were evaluated with brain magnetic resonance imaging (MRI), neuropsychological testing, and dual-energy x-ray absorptiometry to determine whole-body fat and lean masses. Body mass index was calculated as weight in kilograms divided by height in meters squared. Results: Lean mass was reduced in persons with early AD compared with controls without dementia (F=7.73; P=.006) after controlling for sex. Whole-brain volume (β=.20; P<.001), white matter volume (β=.19; P<.001), and global cognitive performance (β=.12; P=.007) were associated with lean mass (dependent variable) when controlling for age and sex. The total body fat and percentage of body fat values were not different across groups or related to cognition and brain volume. Conclusion: Loss of lean mass is accelerated in AD and is associated with brain atrophy and cognitive performance, perhaps as a direct or indirect consequence of AD pathophysiology or through shared mechanisms common to both AD and sarcopenia.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalArchives of Neurology
Volume67
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

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Atrophy
Dementia
Alzheimer Disease
Brain
Adipose Tissue
Cognition
Sarcopenia
Body Composition
Case-Control Studies
Body Mass Index
Magnetic Resonance Imaging
X-Rays
Medicine
Outcome Assessment (Health Care)
Alzheimer's Disease
Weights and Measures
Fat
Cognitive Performance
Rating

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Reduced lean mass in early Alzheimer disease and its association with brain atrophy. / Burns, Jeffrey M.; Johnson, David K; Watts, Amber; Swerdlow, Russell H.; Brooks, William M.

In: Archives of Neurology, Vol. 67, No. 4, 01.04.2010, p. 428-433.

Research output: Contribution to journalArticle

Burns, Jeffrey M. ; Johnson, David K ; Watts, Amber ; Swerdlow, Russell H. ; Brooks, William M. / Reduced lean mass in early Alzheimer disease and its association with brain atrophy. In: Archives of Neurology. 2010 ; Vol. 67, No. 4. pp. 428-433.
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