Abstract
In addition to reduced nerve conduction velocity, diabetic neuropathic patients often exhibit a reduction in the amplitude of the compound muscle action potential elicited by stimulation of the Ia-afferent-mediated reflex pathway (Hoffman or H wave) that can contribute to diminished or absent tendon reflexes. In contrast to nerve conduction velocity deficits, changes in H-wave amplitudes have not been reproduced in diabetic animal models. Using electrophysiological techniques developed for repeated recordings in individual animals, we report H-wave deficits in streptozotocin (STZ)-treated insulin-dependent diabetic rats. After 4 weeks of diabetes induced by STZ treatment, a 47% reduction in the H-wave amplitude was demonstrated by recording compound muscle action potentials in foot muscles after stimulation of Ia afferents. Interestingly, we also demonstrate that the H-wave amplitude gradually recovers to a 26% deficit after 12 weeks of experimental diabetes. The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 220-227 |
| Number of pages | 8 |
| Journal | Experimental Neurology |
| Volume | 172 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Diabetes
- Muscle atrophy
- Neuropathy
- Stz
- Tendon reflex
ASJC Scopus subject areas
- Neurology
- Neuroscience(all)
Cite this
Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats. / Tonra, James R.; Cliffer, Kenneth D.; Carson, Susan R.; Lindsay, Ronald M.; Bodine, Sue C.; DiStefano, Peter S.
In: Experimental Neurology, Vol. 172, No. 1, 2001, p. 220-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced Ia-afferent-mediated Hoffman reflex in streptozotocin-induced diabetic rats
AU - Tonra, James R.
AU - Cliffer, Kenneth D.
AU - Carson, Susan R.
AU - Lindsay, Ronald M.
AU - Bodine, Sue C.
AU - DiStefano, Peter S.
PY - 2001
Y1 - 2001
N2 - In addition to reduced nerve conduction velocity, diabetic neuropathic patients often exhibit a reduction in the amplitude of the compound muscle action potential elicited by stimulation of the Ia-afferent-mediated reflex pathway (Hoffman or H wave) that can contribute to diminished or absent tendon reflexes. In contrast to nerve conduction velocity deficits, changes in H-wave amplitudes have not been reproduced in diabetic animal models. Using electrophysiological techniques developed for repeated recordings in individual animals, we report H-wave deficits in streptozotocin (STZ)-treated insulin-dependent diabetic rats. After 4 weeks of diabetes induced by STZ treatment, a 47% reduction in the H-wave amplitude was demonstrated by recording compound muscle action potentials in foot muscles after stimulation of Ia afferents. Interestingly, we also demonstrate that the H-wave amplitude gradually recovers to a 26% deficit after 12 weeks of experimental diabetes. The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients.
AB - In addition to reduced nerve conduction velocity, diabetic neuropathic patients often exhibit a reduction in the amplitude of the compound muscle action potential elicited by stimulation of the Ia-afferent-mediated reflex pathway (Hoffman or H wave) that can contribute to diminished or absent tendon reflexes. In contrast to nerve conduction velocity deficits, changes in H-wave amplitudes have not been reproduced in diabetic animal models. Using electrophysiological techniques developed for repeated recordings in individual animals, we report H-wave deficits in streptozotocin (STZ)-treated insulin-dependent diabetic rats. After 4 weeks of diabetes induced by STZ treatment, a 47% reduction in the H-wave amplitude was demonstrated by recording compound muscle action potentials in foot muscles after stimulation of Ia afferents. Interestingly, we also demonstrate that the H-wave amplitude gradually recovers to a 26% deficit after 12 weeks of experimental diabetes. The recovery of the H wave in STZ-treated rats distinguishes this deficit mechanistically from other STZ-induced electrophysiological changes and may model a similar recovery of the H wave reported in diabetic patients.
KW - Diabetes
KW - Muscle atrophy
KW - Neuropathy
KW - Stz
KW - Tendon reflex
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UR - http://www.scopus.com/inward/citedby.url?scp=0035214206&partnerID=8YFLogxK
U2 - 10.1006/exnr.2001.7767
DO - 10.1006/exnr.2001.7767
M3 - Article
C2 - 11681854
AN - SCOPUS:0035214206
VL - 172
SP - 220
EP - 227
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -