Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors

Christopher T. Simons, Alvin G. Gogineni, Mirela Iodi Carstens, E. Carstens

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Aversion to capsaicin (0.1-10 ppm) was assessed using a two-bottle paired preference paradigm, before and after intracisternal injection of substance P conjugated to saporin (SP-SAP) to ablate neurons in superficial medullary and cervical dorsal horn that express NK-1 receptors. Before SP-SAP, there was a concentration-dependent decrease in consumption of capsaicin with a threshold of 0.1-0.3 ppm. Following SP-SAP, significantly more capsaicin solution was consumed at 1- and 10-ppm concentrations. These results support a role for substance P in the mediation of high, but not low, levels of capsaicin-induced oral irritation.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalBrain Research
Volume945
Issue number1
DOIs
StatePublished - Jul 26 2002

Keywords

  • Aversion
  • Capsaicin
  • Oral irritation
  • Substance P
  • Trigeminal caudalis

ASJC Scopus subject areas

  • Neuroscience(all)

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