Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy

Allen M. Chen, Joaquin Garcia, M. Kara Bucci, Albert S. Chan, Michael J. Kaplan, Mark I. Singer, Theodore L. Phillips

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background. The optimal treatment for patients with locally recurrent carcinomas of the salivary glands is unclear. Methods. Ninety-nine patients underwent salvage surgery for locally recurrent salivary gland carcinomas. Eighty-one (82%) had previously received radiation. Thirty-seven patients (37%) received intraoperative radiation therapy (IORT) to a median dose of 15 Gy (range, 12-18 Gy) at the time of salvage. Results. The 1-, 3-, and 5-year estimates of local control after salvage surgery were 88%, 75%, and 69%, respectively. A Cox proportional hazard model identified positive margins (0.01) and the omission of IORT (p = .001) as independent predictors of local failure. The 5-year overall survival was 34%. Distant metastasis was the most common site of subsequent failure, occurring in 42% of patients. Conclusions. IORT significantly improves disease control for patients with locally recurrent carcinomas of the salivary glands. The high rate of distant metastasis emphasizes the need for effective systemic therapies.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalHead and Neck
Volume30
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Salivary Glands
Radiotherapy
Carcinoma
Neoplasm Metastasis
Proportional Hazards Models
Radiation
Survival
Therapeutics

Keywords

  • Carcinoma
  • Intraoperative radiation
  • Recurrent
  • Salivary gland
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Chen, A. M., Garcia, J., Bucci, M. K., Chan, A. S., Kaplan, M. J., Singer, M. I., & Phillips, T. L. (2008). Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy. Head and Neck, 30(1), 2-9. https://doi.org/10.1002/hed.20651

Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy. / Chen, Allen M.; Garcia, Joaquin; Bucci, M. Kara; Chan, Albert S.; Kaplan, Michael J.; Singer, Mark I.; Phillips, Theodore L.

In: Head and Neck, Vol. 30, No. 1, 01.2008, p. 2-9.

Research output: Contribution to journalArticle

Chen, AM, Garcia, J, Bucci, MK, Chan, AS, Kaplan, MJ, Singer, MI & Phillips, TL 2008, 'Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy', Head and Neck, vol. 30, no. 1, pp. 2-9. https://doi.org/10.1002/hed.20651
Chen, Allen M. ; Garcia, Joaquin ; Bucci, M. Kara ; Chan, Albert S. ; Kaplan, Michael J. ; Singer, Mark I. ; Phillips, Theodore L. / Recurrent salivary gland carcinomas treated by surgery with or without intraoperative radiation therapy. In: Head and Neck. 2008 ; Vol. 30, No. 1. pp. 2-9.
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N2 - Background. The optimal treatment for patients with locally recurrent carcinomas of the salivary glands is unclear. Methods. Ninety-nine patients underwent salvage surgery for locally recurrent salivary gland carcinomas. Eighty-one (82%) had previously received radiation. Thirty-seven patients (37%) received intraoperative radiation therapy (IORT) to a median dose of 15 Gy (range, 12-18 Gy) at the time of salvage. Results. The 1-, 3-, and 5-year estimates of local control after salvage surgery were 88%, 75%, and 69%, respectively. A Cox proportional hazard model identified positive margins (0.01) and the omission of IORT (p = .001) as independent predictors of local failure. The 5-year overall survival was 34%. Distant metastasis was the most common site of subsequent failure, occurring in 42% of patients. Conclusions. IORT significantly improves disease control for patients with locally recurrent carcinomas of the salivary glands. The high rate of distant metastasis emphasizes the need for effective systemic therapies.

AB - Background. The optimal treatment for patients with locally recurrent carcinomas of the salivary glands is unclear. Methods. Ninety-nine patients underwent salvage surgery for locally recurrent salivary gland carcinomas. Eighty-one (82%) had previously received radiation. Thirty-seven patients (37%) received intraoperative radiation therapy (IORT) to a median dose of 15 Gy (range, 12-18 Gy) at the time of salvage. Results. The 1-, 3-, and 5-year estimates of local control after salvage surgery were 88%, 75%, and 69%, respectively. A Cox proportional hazard model identified positive margins (0.01) and the omission of IORT (p = .001) as independent predictors of local failure. The 5-year overall survival was 34%. Distant metastasis was the most common site of subsequent failure, occurring in 42% of patients. Conclusions. IORT significantly improves disease control for patients with locally recurrent carcinomas of the salivary glands. The high rate of distant metastasis emphasizes the need for effective systemic therapies.

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