Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation

Sindhu Chandran, Kuang-Yu Jen, Zoltan G. Laszik

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A spectrum of kidney diseases besides classic human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) exists in HIV-infected patients. Immune complex-mediated glomerulonephritis has emerged as a significant contributor to the burden of kidney disease in this population, particularly in patients of non-African descent. Lupus-like nephritis, a form of immune complex glomerulonephritis with histologic features identical to lupus nephritis in the absence of clinical or serologic markers of lupus, is well recognized as a cause of end-stage renal disease in HIV-infected patients. None of the HIV-associated kidney lesions, whether classic HIVAN or non-HIVAN, has been reported to recur in kidney transplants. We report here for the first time clinical and histologic recurrence of HIV-associated lupus-like nephritis after successful kidney transplantation, causing proteinuria, hematuria, and impaired kidney transplant function.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume62
Issue number2
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Fingerprint

Lupus Nephritis
AIDS-Associated Nephropathy
Antigen-Antibody Complex
Kidney Transplantation
HIV
Kidney Diseases
Glomerulonephritis
Kidney
Transplants
Hematuria
Proteinuria
Chronic Kidney Failure
Recurrence
Population

Keywords

  • Human immunodeficiency virus (HIV)
  • kidney transplantation
  • lupus nephritis
  • recurrent disease
  • recurrent glomerulonephritis

ASJC Scopus subject areas

  • Nephrology

Cite this

Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation. / Chandran, Sindhu; Jen, Kuang-Yu; Laszik, Zoltan G.

In: American Journal of Kidney Diseases, Vol. 62, No. 2, 01.08.2013, p. 335-338.

Research output: Contribution to journalArticle

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