Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors

28 Dogs (1994-2002)

Bernard Séguin, M. Faulkner Besancon, Jennifer L. McCallan, Loralei L. Dewe, Matthew C. Tenwolde, Emily K. Wong, Michael S Kent

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The objectives of this study were to determine local recurrence rate, clinical outcome, and prognostic value of the number of argyrophylic nucleolar organizer regions (AgNORs), presence of proliferating cell nuclear antigen (PCNA), and number of Ki-67-positive nuclei after incomplete surgical excision of canine cutaneous grade II mast cell tumors (MCTs). This retrospective study included 30 MCTs in 28 dogs. Medical records were examined and follow-up information was obtained from owners and referring veterinarians. Only cases in which excision was incomplete and no anvcillary therapy (other than prednisone) for MCT was given were included. Paraffin-embedded tumor tissues were retrieved for AgNORs, PCNA, and Ki-67 staining. Median follow-up time was 811.5 days. Seven (23.3%) tumors recurred locally. Median time to local recurrence was not reached with a mean of 1,713 days. The estimated proportions of tumors that recurred locally at 1, 2, and 5 years were 17.3, 22.1, and 33.3%, respectively. Eleven (39.3%) dogs developed MCTs at other cutaneous locations. Median progression-free survival was 1,044 days. Median overall survival was 1,426 days. The combination of Ki-67 and PCNA scores was prognostic for local recurrence (P = .03) and development of local recurrence was prognostic for decreased overall survival (P = .04). Results suggest that a minority of incompletely excised MCTs recur. Therefore, ancillary local therapies may not always be necessary. However, local recurrence can negatively affect survival of the affected dogs. Cellular proliferation indices may indicate the likelihood of MCT recurrence after incomplete excision.

Original languageEnglish (US)
Pages (from-to)933-940
Number of pages8
JournalJournal of Veterinary Internal Medicine
Volume20
Issue number4
DOIs
StatePublished - Jul 2006

Fingerprint

excision
mast cells
Mast Cells
cell proliferation
Cell Proliferation
Dogs
Recurrence
Skin
neoplasms
dogs
Neoplasms
proliferating cell nuclear antigen
Proliferating Cell Nuclear Antigen
Nucleolus Organizer Region
nucleolus organizer region
prednisone
therapeutics
Veterinarians
Prednisone
retrospective studies

Keywords

  • Canine
  • Ki-67
  • MIB-1
  • Proliferating cell nuclear antigen

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors : 28 Dogs (1994-2002). / Séguin, Bernard; Besancon, M. Faulkner; McCallan, Jennifer L.; Dewe, Loralei L.; Tenwolde, Matthew C.; Wong, Emily K.; Kent, Michael S.

In: Journal of Veterinary Internal Medicine, Vol. 20, No. 4, 07.2006, p. 933-940.

Research output: Contribution to journalArticle

Séguin, Bernard ; Besancon, M. Faulkner ; McCallan, Jennifer L. ; Dewe, Loralei L. ; Tenwolde, Matthew C. ; Wong, Emily K. ; Kent, Michael S. / Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors : 28 Dogs (1994-2002). In: Journal of Veterinary Internal Medicine. 2006 ; Vol. 20, No. 4. pp. 933-940.
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abstract = "The objectives of this study were to determine local recurrence rate, clinical outcome, and prognostic value of the number of argyrophylic nucleolar organizer regions (AgNORs), presence of proliferating cell nuclear antigen (PCNA), and number of Ki-67-positive nuclei after incomplete surgical excision of canine cutaneous grade II mast cell tumors (MCTs). This retrospective study included 30 MCTs in 28 dogs. Medical records were examined and follow-up information was obtained from owners and referring veterinarians. Only cases in which excision was incomplete and no anvcillary therapy (other than prednisone) for MCT was given were included. Paraffin-embedded tumor tissues were retrieved for AgNORs, PCNA, and Ki-67 staining. Median follow-up time was 811.5 days. Seven (23.3{\%}) tumors recurred locally. Median time to local recurrence was not reached with a mean of 1,713 days. The estimated proportions of tumors that recurred locally at 1, 2, and 5 years were 17.3, 22.1, and 33.3{\%}, respectively. Eleven (39.3{\%}) dogs developed MCTs at other cutaneous locations. Median progression-free survival was 1,044 days. Median overall survival was 1,426 days. The combination of Ki-67 and PCNA scores was prognostic for local recurrence (P = .03) and development of local recurrence was prognostic for decreased overall survival (P = .04). Results suggest that a minority of incompletely excised MCTs recur. Therefore, ancillary local therapies may not always be necessary. However, local recurrence can negatively affect survival of the affected dogs. Cellular proliferation indices may indicate the likelihood of MCT recurrence after incomplete excision.",
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AU - Dewe, Loralei L.

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AU - Wong, Emily K.

AU - Kent, Michael S

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