Recovery of lipid mass after removal of adipose tissue in ground squirrels

Male goldenmantled ground squirrels subjected to surgical removal of substantial portions of inguinal, retroperitoneal, and epididymal adipose tissue [lipectomy (Lipx)] or to sham lipectomy (Sham) during the early prehibernatory fattening phase did not differ in body mass 4 mo later at the time of their annual body weight peaks. Body mass restoration by Lipx squirrels was achieved without compensatory increases in food intake. There was little or no regeneration of epididymal adipose tissue, complete regeneration of the retroperitoneal depot, and an increase in mass of subcutaneous fat of Lipx animals. Epididymal and retroperitoneal adipocytes were equivalent in size in Sham and Lipx squirrels; adipocytes in subcutaneous fat were 20% larger in Lipx than in Sham animals. Generation of the annual body mass cycle of this ground squirrel involves active regulation of the lipid mass.