Abstract
Purpose: Characterize recovery kinetics of fish cone ohotoresoonses. Method: We recorded photocurrents of green sunfish and goldfish single cones in fish Ringer's at room temperature with suction electrodes in response to brief flashes covering 3-4 log units of intensity. Results: In response to saturating (or nearly saturating) flashes fish cone photocurrents exhibit two distinct recovery components: an initial, rapid component (1) which accounts for most of the recovery to justsaturating flashes, and a second, slower component (2). Component (1) is nearly isomorphic over flash intensity, and translates on the time axis for near-saturating intensities with distinct increment te per e-fold change in flash intensity. For different cones T, ranges from 40 to 200 ms (avg. TC = 95 ms for 10 cones). Component (2) progressively increases in relative magnitude and apparent time constant at higher intensities. Conclusion: By analogy to recent analyses of rod photocurrent recovery, TC (component 1) may represent the lifetime of the cone G, while component (2) may be caused by a slowly inactivatinq but low specific activity form of cone R.
| Original language | English (US) |
|---|---|
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 38 |
| Issue number | 4 |
| State | Published - 1997 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Ophthalmology
Cite this
Recovery components of fish cone photoresponses. / Zhang, L. L.; Nikonov, S. S.; Bronk, P. M.; Pugh Jr, Edward N.
In: Investigative Ophthalmology and Visual Science, Vol. 38, No. 4, 1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recovery components of fish cone photoresponses
AU - Zhang, L. L.
AU - Nikonov, S. S.
AU - Bronk, P. M.
AU - Pugh Jr, Edward N
PY - 1997
Y1 - 1997
N2 - Purpose: Characterize recovery kinetics of fish cone ohotoresoonses. Method: We recorded photocurrents of green sunfish and goldfish single cones in fish Ringer's at room temperature with suction electrodes in response to brief flashes covering 3-4 log units of intensity. Results: In response to saturating (or nearly saturating) flashes fish cone photocurrents exhibit two distinct recovery components: an initial, rapid component (1) which accounts for most of the recovery to justsaturating flashes, and a second, slower component (2). Component (1) is nearly isomorphic over flash intensity, and translates on the time axis for near-saturating intensities with distinct increment te per e-fold change in flash intensity. For different cones T, ranges from 40 to 200 ms (avg. TC = 95 ms for 10 cones). Component (2) progressively increases in relative magnitude and apparent time constant at higher intensities. Conclusion: By analogy to recent analyses of rod photocurrent recovery, TC (component 1) may represent the lifetime of the cone G, while component (2) may be caused by a slowly inactivatinq but low specific activity form of cone R.
AB - Purpose: Characterize recovery kinetics of fish cone ohotoresoonses. Method: We recorded photocurrents of green sunfish and goldfish single cones in fish Ringer's at room temperature with suction electrodes in response to brief flashes covering 3-4 log units of intensity. Results: In response to saturating (or nearly saturating) flashes fish cone photocurrents exhibit two distinct recovery components: an initial, rapid component (1) which accounts for most of the recovery to justsaturating flashes, and a second, slower component (2). Component (1) is nearly isomorphic over flash intensity, and translates on the time axis for near-saturating intensities with distinct increment te per e-fold change in flash intensity. For different cones T, ranges from 40 to 200 ms (avg. TC = 95 ms for 10 cones). Component (2) progressively increases in relative magnitude and apparent time constant at higher intensities. Conclusion: By analogy to recent analyses of rod photocurrent recovery, TC (component 1) may represent the lifetime of the cone G, while component (2) may be caused by a slowly inactivatinq but low specific activity form of cone R.
UR - http://www.scopus.com/inward/record.url?scp=33749224225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749224225&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33749224225
VL - 38
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 4
ER -