Abstract
Epileptogenic foci were produced by iontophoresis of cobaltous chloride onto cat cortex. The epileptiform discharge, as recorded with a surface electroencephalogram electrode, was characterized by an initial large amplitude spike followed by prominent afterdischarge. The focus was restricted in its lateral extent and appeared to be confined pricipally to the superficial layers of cortex. Most cells recorded in the upper half of the cortex showed excitatory patterns of activity correlated with surface epileptiform events; deeper in the cortex, increasing numbers of cells were inhibited or not affected during the surface discharge. The maximum duration of spontaneous epileptogenesis induced by cobalt iontophoresis was 24 hr.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 353-367 |
| Number of pages | 15 |
| Journal | Experimental Neurology |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Recordings from cortical epileptogenic foci induced by cobalt iontophoresis. / Schwartzkroin, Philip A; Shimada, Yasuo; Bromley, Bryann.
In: Experimental Neurology, Vol. 55, No. 2, 1977, p. 353-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recordings from cortical epileptogenic foci induced by cobalt iontophoresis
AU - Schwartzkroin, Philip A
AU - Shimada, Yasuo
AU - Bromley, Bryann
PY - 1977
Y1 - 1977
N2 - Epileptogenic foci were produced by iontophoresis of cobaltous chloride onto cat cortex. The epileptiform discharge, as recorded with a surface electroencephalogram electrode, was characterized by an initial large amplitude spike followed by prominent afterdischarge. The focus was restricted in its lateral extent and appeared to be confined pricipally to the superficial layers of cortex. Most cells recorded in the upper half of the cortex showed excitatory patterns of activity correlated with surface epileptiform events; deeper in the cortex, increasing numbers of cells were inhibited or not affected during the surface discharge. The maximum duration of spontaneous epileptogenesis induced by cobalt iontophoresis was 24 hr.
AB - Epileptogenic foci were produced by iontophoresis of cobaltous chloride onto cat cortex. The epileptiform discharge, as recorded with a surface electroencephalogram electrode, was characterized by an initial large amplitude spike followed by prominent afterdischarge. The focus was restricted in its lateral extent and appeared to be confined pricipally to the superficial layers of cortex. Most cells recorded in the upper half of the cortex showed excitatory patterns of activity correlated with surface epileptiform events; deeper in the cortex, increasing numbers of cells were inhibited or not affected during the surface discharge. The maximum duration of spontaneous epileptogenesis induced by cobalt iontophoresis was 24 hr.
UR - http://www.scopus.com/inward/record.url?scp=0017647891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017647891&partnerID=8YFLogxK
U2 - 10.1016/0014-4886(77)90006-1
DO - 10.1016/0014-4886(77)90006-1
M3 - Article
C2 - 858326
AN - SCOPUS:0017647891
VL - 55
SP - 353
EP - 367
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -