Reconfigurable microfluidic dilution generation for quantitative assay

Jinzhen Fan; Baoqing Li; Tingrui Pan

doi:10.1109/MEMSYS.2015.7051012

Reconfigurable microfluidic dilution generation for quantitative assay

Jinzhen Fan, Baoqing Li, Tingrui Pan

Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

In this paper, we present a reconfigurable microfluidic dilution device for high-throughput quantitative assays, without the assistance of continuous fluidic pump or vacuum source. This device is capable to produce discrete logarithmic concentration profiles ranging from 1 to 100 fold dilution in parallel from a fixed sample volume (e.g., 10 μL). To facilitate mixing and reactions in the chambers, two acoustic microstreaming actuation mechanisms have been investigated for easy integratability and accessibility. We characterized the dilution performance by both colorimetric and fluorescent means.

Original language	English (US)
Article number	7051012
Pages (from-to)	543-546
Number of pages	4
Journal	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2015-February
Issue number	February
DOIs	https://doi.org/10.1109/MEMSYS.2015.7051012
State	Published - Jan 1 2015
Event	2015 28th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2015 - Estoril, Portugal Duration: Jan 18 2015 → Jan 22 2015

ASJC Scopus subject areas

Electrical and Electronic Engineering
Mechanical Engineering
Condensed Matter Physics
Electronic, Optical and Magnetic Materials

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AB - In this paper, we present a reconfigurable microfluidic dilution device for high-throughput quantitative assays, without the assistance of continuous fluidic pump or vacuum source. This device is capable to produce discrete logarithmic concentration profiles ranging from 1 to 100 fold dilution in parallel from a fixed sample volume (e.g., 10 μL). To facilitate mixing and reactions in the chambers, two acoustic microstreaming actuation mechanisms have been investigated for easy integratability and accessibility. We characterized the dilution performance by both colorimetric and fluorescent means.

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