The year 2004 marks the fortieth anniversary of the Holliday junction. This extraordinary DNA structure, originally proposed by Robin Holliday to explain genetic recombination in fungi, now appears to be a pivotal intermediate in many aspects of DNA metabolism. In those forty years the Holliday junction has gone from a hypothetical structure to models for its atomic structure and visualization of its dynamics at the single molecule level.
ASJC Scopus subject areas
- Molecular Biology