Recombinant human gonadotropins for macaque superovulation: Repeated stimulations and post-treatment pregnancies

C. A. Vandevoort, Alice F Tarantal

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This report summarizes data from the superovulation and ultrasound-guided follicular aspiration of 40 female rhesus monkeys (Macaca mulatta) with recombinant human gonadotropins. Of the animals treated, 12 were stimulated for only one cycle, either because of a poor response to the hormones or due to ectopic ovarian position precluding ease of access via ultrasound. The majority of animals were stimulated for a minimum of 3 cycles and 3 females continued to respond for a minimum of 8 and a maximum of 10 cycles. For those animals with repeated stimulation cycles, the number of follicles developed during each of the stimulation protocols remained relatively comparable. Of the animals mated since cessation of treatment, 70% conceived. There was no difference between the conception rate in this subset of animals and the rest of the macaque breeding colony. These data indicate that participation in these studies does not impact on the reproductive potential of female rhesus monkeys.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalJournal of Medical Primatology
Issue number6
StatePublished - 2001


  • Assisted reproduction
  • Conception
  • In vitro fertilization
  • In vitro maturation
  • Macaca mulatta
  • Ultrasound

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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