Recombinant DNA approaches to feline leukemia virus immunization.

Paul A Luciw, D. Parkes, G. Van Nest, D. Dina, K. Hendrix, M. B. Gardner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We have utilized 2 recombinant DNA strategies for immunization against FeLV in cats: (a) modified live virus was attenuated by mutation and recombination, and (b) an immunogen, consisting of subunit envelope protein, was prepared in genetically engineered yeast. Results indicated that the genetically manipulated live virus preparations were not protective against FeLV challenge because they were either not attenuated in virulence or were not sufficiently antigenic. Immunization with yeast-synthesized FeLV envelope protein followed by the modified live virus gave protective immunity in cats under experimental conditions. Future immunization attempts will concentrate on enhancing the immunogenic potency of the yeast- synthesized FeLV envelope protein.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalBasic Life Sciences
Volume37
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Luciw, P. A., Parkes, D., Van Nest, G., Dina, D., Hendrix, K., & Gardner, M. B. (1986). Recombinant DNA approaches to feline leukemia virus immunization. Basic Life Sciences, 37, 207-215.