Recombinant bacille calmette-guerin expressing the measles virus nucleoprotein protects infant rhesus macaques from measles virus pneumonia

Y. D. Zhu, G. Fennelly, Chris J Miller, R. Tarara, I. Saxe, B. Bloom, M. McChesney

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Measles virus infection continues to be a major cause of infant mortality. There is a need for a measles vaccine that can be administered at birth in the presence of maternal neutralizing antibody. Infant rhesus monkeys were immunized with recombinant bacille Calmette-Guerin expressing the full-length measles virus nucleoprotein (BCG-N) and subsequently challenged with measles virus. Nucleoprotein-specific lymphocyte proliferative responses were detected in the absence of anti-N antibody after vaccination. Vaccination with BCG-N did not prevent systemic measles virus infection; however, there was a significant reduction of lung inflammation after challenge. Virus titers in lymph nodes were significantly lower, and the duration of nasopharyngeal vital shedding was shorter in some vaccinated monkeys after challenge. These results suggest that measles virus-specific T cells were primed by BCG-N vaccination and that they prevented virus-induced lung pathology.

Original languageEnglish (US)
Pages (from-to)1445-1453
Number of pages9
JournalJournal of Infectious Diseases
Volume176
Issue number6
StatePublished - 1997

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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