Recollection and familiarity in schizophrenia

A quantitative review

Laura A. Libby, Andrew P. Yonelinas, Charan Ranganath, John D Ragland

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Recognition memory judgments can be based on recollection of qualitative information about an earlier study event or on assessments of stimulus familiarity. Schizophrenia is associated with pronounced deficits in overall recognition memory, and these deficits are highly predictive of global functioning. However, the extent to which these deficits reflect impairments in recollection or familiarity is less well understood. In the current article, we reviewed studies that used remember-know-new, process dissociation, and receiver operating characteristic procedures to investigate recollection and familiarity in schizophrenia. We also performed a quantitative reanalysis of these study results to obtain recollection and familiarity estimates that account for methodological differences between studies. Contrary to previous conclusions that recollection is selectively impaired in schizophrenia, we found evidence for both familiarity and recollection deficits across studies, suggesting multi-focal medial temporal lobe and/or prefrontal cortex dysfunction. The familiarity deficits were more variable with frequent small-to-medium rather than medium-to-large effect sizes, suggesting that familiarity could be potentially used as a compensatory ability, whereas recollection is conceptualized as a therapeutic target for new treatment development.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalBiological Psychiatry
Volume73
Issue number10
DOIs
StatePublished - May 15 2013

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Schizophrenia
Temporal Lobe
Dissociative Disorders
Recognition (Psychology)
Aptitude
Memory Disorders
Prefrontal Cortex
ROC Curve

Keywords

  • Episodic memory
  • familiarity
  • medial temporal lobe
  • memory retrieval
  • recollection
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Recollection and familiarity in schizophrenia : A quantitative review. / Libby, Laura A.; Yonelinas, Andrew P.; Ranganath, Charan; Ragland, John D.

In: Biological Psychiatry, Vol. 73, No. 10, 15.05.2013, p. 944-950.

Research output: Contribution to journalArticle

Libby, Laura A. ; Yonelinas, Andrew P. ; Ranganath, Charan ; Ragland, John D. / Recollection and familiarity in schizophrenia : A quantitative review. In: Biological Psychiatry. 2013 ; Vol. 73, No. 10. pp. 944-950.
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