Recognizing calcific uremic arteriolopathy in autoimmune disease: An emerging mimicker of vasculitis

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23 Scopus citations


Calcinosis has long been associated with autoimmune disease and has a distinctive profile in scleroderma, dermatomyositis, systemic lupus erythematosus, and overlap syndromes. However, there have also been a number of case studies of calcific uremic arteriolopathy, or calciphylaxis, described within vessels, including patients with chronic renal insufficiency and several forms of vasculitis. Interestingly, the calciphylaxis associated with vasculitis appears to be unique, although relatively uncommon and is likely secondary to a disruption in the calcium-phosphate-parathyroid hormone axis. However, there appears to be an additional trigger, given that calciphylaxis is seen both in the absence of chronic kidney disease, and in the absence of a deranged calcium-phosphate-parathyroid hormone axis. These additional triggers include a high female predominance, obesity, diabetes and, possibly, warfarin use. In this review, we describe the clinical features of calciphylaxis, particularly in the context of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)638-643
Number of pages6
JournalAutoimmunity Reviews
Issue number8
StatePublished - Sep 2008


  • Autoimmunity
  • Calcinosis cutis
  • Calciphylaxis
  • Scleroderma
  • Small vessel calcification

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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