Abstract
(Formula Presented) The DNA repair adenine glycosylase MutY efficiently recognizes 7-deaza-2′-deoxyadenosine (Z) and its nonpolar isostere 4-methylindole β-deoxynucleoside (M) opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine (OG) and G in DNA. Both wild-type and truncated MutY exhibit a 10-to 20-fold higher affinity for a duplex containing OG:M than OG:Z. More efficient recognition of M over Z by MutY may be to due the lack of hydrogen bonding with the OG that facilitates nucleotide flipping during the substrate recognition process.
Original language | English (US) |
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Pages (from-to) | 1341-1344 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 2 |
Issue number | 9 |
State | Published - May 4 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine