Abstract
(Formula Presented) The DNA repair adenine glycosylase MutY efficiently recognizes 7-deaza-2′-deoxyadenosine (Z) and its nonpolar isostere 4-methylindole β-deoxynucleoside (M) opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine (OG) and G in DNA. Both wild-type and truncated MutY exhibit a 10-to 20-fold higher affinity for a duplex containing OG:M than OG:Z. More efficient recognition of M over Z by MutY may be to due the lack of hydrogen bonding with the OG that facilitates nucleotide flipping during the substrate recognition process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1341-1344 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 2 |
| Issue number | 9 |
| State | Published - May 4 2000 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
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Cite this
Chepanoske, C. L., Langelier, C. R., Chmiel, N. H., & David, S. S. (2000). Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY. Organic Letters, 2(9), 1341-1344.