Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase

Jinzi J. Wu, Daniel E H Afar, Hoang Phan, Owen N. Witte, Kit Lam

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Using a combinatorial peptide library that is based on the one-bead one-peptide approach we identified 14 peptide substrates for the c-ABL protein tyrosine kinase, which define three distinct consensus sequence groups. This is distinct from many serine/threonine kinases, which often phosphorylate only one major consensus sequence. The three consensus sequences accurately predict phosphorylation sites in cellular ABL substrates proven to play a role in cell signaling. Our data suggest that protein tyrosine kinases have evolved to recognize multiple substrate motifs.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalCombinatorial Chemistry and High Throughput Screening
Volume5
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Clinical Biochemistry
  • Pharmacology

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