Using a combinatorial peptide library that is based on the one-bead one-peptide approach we identified 14 peptide substrates for the c-ABL protein tyrosine kinase, which define three distinct consensus sequence groups. This is distinct from many serine/threonine kinases, which often phosphorylate only one major consensus sequence. The three consensus sequences accurately predict phosphorylation sites in cellular ABL substrates proven to play a role in cell signaling. Our data suggest that protein tyrosine kinases have evolved to recognize multiple substrate motifs.
|Original language||English (US)|
|Number of pages||9|
|Journal||Combinatorial Chemistry and High Throughput Screening|
|State||Published - 2002|
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Clinical Biochemistry