Abstract
Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1003-1008 |
| Number of pages | 6 |
| Journal | Molecular Immunology |
| Volume | 40 |
| Issue number | 14-15 |
| DOIs | |
| State | Published - Feb 2004 |
| Externally published | Yes |
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Keywords
- Autoimmunity
- Cancer
- Degeneracy
- Molecular mimicry
- Self-recognition
- TCR
ASJC Scopus subject areas
- Molecular Biology
- Immunology
Cite this
Recognition and function in a degenerate immune system. / Sercarz, Eli E.; Maverakis, Emanual Michael.
In: Molecular Immunology, Vol. 40, No. 14-15, 02.2004, p. 1003-1008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recognition and function in a degenerate immune system
AU - Sercarz, Eli E.
AU - Maverakis, Emanual Michael
PY - 2004/2
Y1 - 2004/2
N2 - Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.
AB - Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.
KW - Autoimmunity
KW - Cancer
KW - Degeneracy
KW - Molecular mimicry
KW - Self-recognition
KW - TCR
UR - http://www.scopus.com/inward/record.url?scp=1242270587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1242270587&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2003.11.002
DO - 10.1016/j.molimm.2003.11.002
M3 - Article
C2 - 15036903
AN - SCOPUS:1242270587
VL - 40
SP - 1003
EP - 1008
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 14-15
ER -