Recognition and function in a degenerate immune system

Eli E. Sercarz; Emanual Michael Maverakis

doi:10.1016/j.molimm.2003.11.002

Recognition and function in a degenerate immune system

Eli E. Sercarz, Emanual Michael Maverakis

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.

Original language	English (US)
Pages (from-to)	1003-1008
Number of pages	6
Journal	Molecular Immunology
Volume	40
Issue number	14-15
DOIs	https://doi.org/10.1016/j.molimm.2003.11.002
State	Published - Feb 2004
Externally published	Yes

Keywords

Autoimmunity
Cancer
Degeneracy
Molecular mimicry
Self-recognition
TCR

ASJC Scopus subject areas

Molecular Biology
Immunology

Access to Document

10.1016/j.molimm.2003.11.002

Fingerprint Dive into the research topics of 'Recognition and function in a degenerate immune system'. Together they form a unique fingerprint.

Cite this

@article{579e2af983dd42b6b7691f385e2bba2f,

title = "Recognition and function in a degenerate immune system",

abstract = "Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.",

keywords = "Autoimmunity, Cancer, Degeneracy, Molecular mimicry, Self-recognition, TCR",

author = "Sercarz, {Eli E.} and Maverakis, {Emanual Michael}",

year = "2004",

month = feb,

doi = "10.1016/j.molimm.2003.11.002",

language = "English (US)",

volume = "40",

pages = "1003--1008",

journal = "Molecular Immunology",

issn = "0161-5890",

publisher = "Elsevier Limited",

number = "14-15",

}

TY - JOUR

T1 - Recognition and function in a degenerate immune system

AU - Sercarz, Eli E.

AU - Maverakis, Emanual Michael

PY - 2004/2

Y1 - 2004/2

N2 - Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.

AB - Degeneracy in the immune system not only refers to the recognition by its specific receptors, but also at the level of functional degeneracy of reactivity by its lymphocytes. Features of the immune system such as dominance and competition occur at each of these two levels. Another characteristic of the immune system as a fuzzy system, is its continuum of states, where difficult choices lead to the emergence of unpredictable phenotypes.

KW - Autoimmunity

KW - Cancer

KW - Degeneracy

KW - Molecular mimicry

KW - Self-recognition

KW - TCR

UR - http://www.scopus.com/inward/record.url?scp=1242270587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242270587&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2003.11.002

DO - 10.1016/j.molimm.2003.11.002

M3 - Article

C2 - 15036903

AN - SCOPUS:1242270587

VL - 40

SP - 1003

EP - 1008

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 14-15

ER -