Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek, Moran Rubinstein, Todd Scheuer, James Trimmer

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

Original languageEnglish (US)
Pages (from-to)15363-15373
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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