Abstract
Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15363-15373 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 22 |
| DOIs | |
| State | Published - May 30 2014 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
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Baek, J. H., Rubinstein, M., Scheuer, T., & Trimmer, J. (2014). Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures. Journal of Biological Chemistry, 289(22), 15363-15373. https://doi.org/10.1074/jbc.M114.562785