Abstract
Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.
Original language | English (US) |
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Pages (from-to) | 15363-15373 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 22 |
DOIs | |
State | Published - May 30 2014 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology