Abstract
Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15363-15373 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 22 |
| DOIs | |
| State | Published - May 30 2014 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology