Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek; Moran Rubinstein; Todd Scheuer; James Trimmer

doi:10.1074/jbc.M114.562785

Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek, Moran Rubinstein, Todd Scheuer, James Trimmer

Physiology and Membrane Biology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

Original language	English (US)
Pages (from-to)	15363-15373
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M114.562785
State	Published - May 30 2014

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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abstract = "Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.",

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