Recessive-lethal nonsense suppressors in Salmonella typhimurium

Charles G. Miller; John R. Roth

doi:10.1016/0022-2836(71)90413-X

Recessive-lethal nonsense suppressors in Salmonella typhimurium

Charles G. Miller, John R. Roth

Microbiology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A recessive-lethal UGA suppressor and a recessive-lethal amber suppressor have been characterized in strains of Salmonella typhimurium merodiploid for the ilvmetE region of the chromosome. Both suppressors are greater than 50% efficient and both are co-transducible with ilvE. The suppressors can be transduced into haploid strains but the transductants are unstable and appear to contain duplications of the sup locus. The amber suppressor and the UGA suppressor appear to arise from a common gene.

Original language	English (US)
Pages (from-to)	63-75
Number of pages	13
Journal	Journal of Molecular Biology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1016/0022-2836(71)90413-X
State	Published - Jul 14 1971

ASJC Scopus subject areas

Virology

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abstract = "A recessive-lethal UGA suppressor and a recessive-lethal amber suppressor have been characterized in strains of Salmonella typhimurium merodiploid for the ilvmetE region of the chromosome. Both suppressors are greater than 50% efficient and both are co-transducible with ilvE. The suppressors can be transduced into haploid strains but the transductants are unstable and appear to contain duplications of the sup locus. The amber suppressor and the UGA suppressor appear to arise from a common gene.",

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AB - A recessive-lethal UGA suppressor and a recessive-lethal amber suppressor have been characterized in strains of Salmonella typhimurium merodiploid for the ilvmetE region of the chromosome. Both suppressors are greater than 50% efficient and both are co-transducible with ilvE. The suppressors can be transduced into haploid strains but the transductants are unstable and appear to contain duplications of the sup locus. The amber suppressor and the UGA suppressor appear to arise from a common gene.

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