Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain

E. S. Anton, H. T. Ghashghaei, Janet L. Weber, Corey McCann, Tobias M. Fischer, Isla D. Cheung, Martin Gassmann, Albee Messing, Rudiger Klein, Markus H. Schwab, Kevin C K Lloyd, Cary Lai

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Neural progenitor proliferation, differentiation and migration are continually active in the rostral migratory stream of the adult brain. Here, we show that the receptor tyrosine kinase ErbB4 is expressed prominently by the neuroblasts present in the subventricular zone and the rostral migratory stream. The neuregulins (NRG1-NRG3), which have been identified as ErbB4 ligands, are detected either in the stream or in adjacent regions. Mice deficient in ErbB4 expressed under the control of either the nestin or the hGFAP promoter have altered neuroblast chain organization and migration and deficits in the placement and differentiation of olfactory interneurons. These findings suggest that ErbB4 activation helps to regulate the organization of neural chains that form the rostral migratory stream and influences the differentiation of olfactory interneuronal precursors.

Original languageEnglish (US)
Pages (from-to)1319-1328
Number of pages10
JournalNature Neuroscience
Volume7
Issue number12
DOIs
StatePublished - Dec 2004

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Neuregulins
Nestin
Lateral Ventricles
Emigration and Immigration
Receptor Protein-Tyrosine Kinases
Interneurons
Prosencephalon
Organizations
Ligands
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anton, E. S., Ghashghaei, H. T., Weber, J. L., McCann, C., Fischer, T. M., Cheung, I. D., ... Lai, C. (2004). Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nature Neuroscience, 7(12), 1319-1328. https://doi.org/10.1038/nn1345

Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. / Anton, E. S.; Ghashghaei, H. T.; Weber, Janet L.; McCann, Corey; Fischer, Tobias M.; Cheung, Isla D.; Gassmann, Martin; Messing, Albee; Klein, Rudiger; Schwab, Markus H.; Lloyd, Kevin C K; Lai, Cary.

In: Nature Neuroscience, Vol. 7, No. 12, 12.2004, p. 1319-1328.

Research output: Contribution to journalArticle

Anton, ES, Ghashghaei, HT, Weber, JL, McCann, C, Fischer, TM, Cheung, ID, Gassmann, M, Messing, A, Klein, R, Schwab, MH, Lloyd, KCK & Lai, C 2004, 'Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain', Nature Neuroscience, vol. 7, no. 12, pp. 1319-1328. https://doi.org/10.1038/nn1345
Anton ES, Ghashghaei HT, Weber JL, McCann C, Fischer TM, Cheung ID et al. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nature Neuroscience. 2004 Dec;7(12):1319-1328. https://doi.org/10.1038/nn1345
Anton, E. S. ; Ghashghaei, H. T. ; Weber, Janet L. ; McCann, Corey ; Fischer, Tobias M. ; Cheung, Isla D. ; Gassmann, Martin ; Messing, Albee ; Klein, Rudiger ; Schwab, Markus H. ; Lloyd, Kevin C K ; Lai, Cary. / Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. In: Nature Neuroscience. 2004 ; Vol. 7, No. 12. pp. 1319-1328.
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