Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders

Ashkan Aryaei, Natalia Vapniarsky Arzi, Jerry C. Hu, Kyriacos A. Athanasiou

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Temporomandibular disorders (TMDs) are among the most common maxillofacial complaints and a major cause of orofacial pain. Although current treatments provide short- and long-term relief, alternative tissue engineering solutions are in great demand. Particularly, the development of strategies, providing long-term resolution of TMD to help patients regain normal function, is a high priority. An absolute prerequisite of tissue engineering is to understand normal structure and function. The current knowledge of anatomical, mechanical, and biochemical characteristics of the temporomandibular joint (TMJ) and associated tissues will be discussed, followed by a brief description of current TMD treatments. The main focus is on recent tissue engineering developments for regenerating TMJ tissue components, with or without a scaffold. The expectation for effectively managing TMD is that tissue engineering will produce biomimetic TMJ tissues that recapitulate the normal structure and function of the TMJ.

Original languageEnglish (US)
Pages (from-to)269-279
Number of pages11
JournalCurrent Osteoporosis Reports
Issue number6
StatePublished - Dec 1 2016


  • Condylar fibrocartilage
  • Scaffold-based tissue engineering
  • Scaffold-free tissue engineering
  • Temporomandibular joint disc
  • Temporomandibular joint disorder
  • TMD treatment methods

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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