Recent progress in chemical synthesis of bacterial surface glycans

Riyao Li, Hai Yu, Xi Chen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan–protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.

Original languageEnglish (US)
Pages (from-to)121-136
Number of pages16
JournalCurrent Opinion in Chemical Biology
StatePublished - Oct 2020


  • Bacterial glycan
  • Carbohydrate
  • Glycoconjugate vaccine
  • Glycosyltransferase
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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